BIOMAT Database Logo BIOMAT Database Logo

Lipoprotein(a) concentrations in Mexican Americans and non-Hispanic whites: the San Antonio Heart Study. 1992

S M Haffner, and K K Gruber, and P A Morales, and H P Hazuda, and R A Valdez, and B D Mitchell, and M P Stern
Department of Medicine, University of Texas Health Science Center at San Antonio 78284-7873.

There is considerable evidence that lipoprotein(a) (Lp(a)) is a strong independent risk factor for coronary heart disease. Based on their risk factor profile, Mexican Americans have an increased risk of coronary heart disease, yet Mexican Americans have coronary heart disease mortality similar to or lower than that of non-Hispanic whites. The authors therefore attempted to determine whether Mexican Americans had decreased Lp(a) concentrations relative to non-Hispanic whites in the San Antonio Heart Study, a population-based study of diabetes and cardiovascular disease. Lp(a) concentrations (mg/dl) were significantly lower in Mexican Americans (n = 316) than in non-Hispanic whites (n = 242) (men: 10.4 vs. 16.3; women: 11.5 vs. 16.4). In addition, the proportion of persons with Lp(a) concentrations of > or = 30 mg/dl (the threshold at which increased risk of coronary heart disease is believed to occur) was significantly higher in non-Hispanic whites than in Mexican Americans (18.6% vs. 7.6%; Mantel-Haenszel odds ratio (adjusted for sex) = 2.79). Age, obesity, body fat distribution, cigarette smoking, alcohol consumption, and glucose and insulin concentrations were not significantly related to Lp(a) levels. Decreased Lp(a) concentrations may account in part for Mexican Americans' relative protection from coronary heart disease mortality.

UI MeSH Term Description Entries
D007328 Insulin A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1). Iletin,Insulin A Chain,Insulin B Chain,Insulin, Regular,Novolin,Sodium Insulin,Soluble Insulin,Chain, Insulin B,Insulin, Sodium,Insulin, Soluble,Regular Insulin
D008297 Male Males
D008800 Mexico A country in NORTH AMERICA, bordering the Caribbean Sea and the Gulf of Mexico, between BELIZE and the UNITED STATES, and bordering the North Pacific Ocean, between Guatemala and the UNITED STATES.
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D009765 Obesity A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).
D012044 Regression Analysis Procedures for finding the mathematical function which best describes the relationship between a dependent variable and one or more independent variables. In linear regression (see LINEAR MODELS) the relationship is constrained to be a straight line and LEAST-SQUARES ANALYSIS is used to determine the best fit. In logistic regression (see LOGISTIC MODELS) the dependent variable is qualitative rather than continuously variable and LIKELIHOOD FUNCTIONS are used to find the best relationship. In multiple regression, the dependent variable is considered to depend on more than a single independent variable. Regression Diagnostics,Statistical Regression,Analysis, Regression,Analyses, Regression,Diagnostics, Regression,Regression Analyses,Regression, Statistical,Regressions, Statistical,Statistical Regressions
D001786 Blood Glucose Glucose in blood. Blood Sugar,Glucose, Blood,Sugar, Blood
D001824 Body Constitution The physical characteristics of the body, including the mode of performance of functions, the activity of metabolic processes, the manner and degree of reactions to stimuli, and power of resistance to the attack of pathogenic organisms. Body Constitutions,Constitution, Body,Constitutions, Body
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man

Related Publications

S M Haffner, and K K Gruber, and P A Morales, and H P Hazuda, and R A Valdez, and B D Mitchell, and M P Stern
Myocardial infarction in Mexican-Americans and non-Hispanic whites. The San Antonio Heart Study.
January 1991, Circulation,
S M Haffner, and K K Gruber, and P A Morales, and H P Hazuda, and R A Valdez, and B D Mitchell, and M P Stern
Risk factors for cardiovascular mortality in Mexican Americans and non-Hispanic whites. San Antonio Heart Study.
March 1990, American journal of epidemiology,
S M Haffner, and K K Gruber, and P A Morales, and H P Hazuda, and R A Valdez, and B D Mitchell, and M P Stern
Eight-year incidence of hypertension in Mexican-Americans and non-Hispanic whites. The San Antonio Heart Study.
March 1992, American journal of hypertension,
S M Haffner, and K K Gruber, and P A Morales, and H P Hazuda, and R A Valdez, and B D Mitchell, and M P Stern
Migration status, socioeconomic status, and mortality rates in Mexican Americans and non-Hispanic whites: the San Antonio Heart Study.
July 1996, Annals of epidemiology,
S M Haffner, and K K Gruber, and P A Morales, and H P Hazuda, and R A Valdez, and B D Mitchell, and M P Stern
Mortality differences between elderly Mexican Americans and non-Hispanic whites in San Antonio, Texas.
June 1994, Journal of the American Geriatrics Society,
S M Haffner, and K K Gruber, and P A Morales, and H P Hazuda, and R A Valdez, and B D Mitchell, and M P Stern
Plasma oxidizability in Mexican-Americans and non-Hispanic whites.
July 1996, Metabolism: clinical and experimental,
S M Haffner, and K K Gruber, and P A Morales, and H P Hazuda, and R A Valdez, and B D Mitchell, and M P Stern
Diabetic retinopathy in Mexican Americans and non-Hispanic whites.
July 1988, Diabetes,
S M Haffner, and K K Gruber, and P A Morales, and H P Hazuda, and R A Valdez, and B D Mitchell, and M P Stern
Gallstone characteristics in Mexican Americans and non-Hispanic whites.
October 1994, Digestive diseases and sciences,
S M Haffner, and K K Gruber, and P A Morales, and H P Hazuda, and R A Valdez, and B D Mitchell, and M P Stern
Dietary intakes of macronutrients among Mexican Americans and Anglo Americans: the San Antonio heart study.
December 1985, The American journal of clinical nutrition,
S M Haffner, and K K Gruber, and P A Morales, and H P Hazuda, and R A Valdez, and B D Mitchell, and M P Stern
Stroke Quality Measures in Mexican Americans and Non-Hispanic Whites.
January 2017, Journal of health disparities research and practice,
Copied contents to your clipboard!