BIOMAT Database Logo BIOMAT Database Logo

Low-dose remifentanil infusion does not impair natural killer cell function in healthy volunteers. 2003

A J Cronin, and N M Aucutt-Walter, and T Budinetz, and C P Bonafide, and N A DiVittore, and V Gordin, and H G Schuler, and R H Bonneau
Penn State College of Medicine, Milton S Hershey Medical Center, 500 University Drive, H187, Hershey, PA 17033, USA. acronin@psu.edu

BACKGROUND Mu opioid agonists suppress natural killer (NK) cell activity in animal models. Studies in human volunteers, however, have yielded conflicting results, with morphine suppressing and fentanyl increasing NK cell activity. This study evaluated the effect of a constant 8-h infusion of remifentanil on NK cell number and function in human volunteers. METHODS After IRB approval and informed consent was obtained, 10 healthy volunteers underwent an 11 pm to 7 am infusion of saline, and at least 1 week later an infusion of 0.02-0.04 microg x kg(-1) min(-1) remifentanil. Blood was collected at 7 am for measurement of NK cell cytotoxicity using a (51)Cr release assay and measurement of NK cell number using fluorescent flow cytometry. RESULTS Median and range of the total NK cell cytotoxicity (KU ml(-1)) was 745.0 (498.3-1483.6) on the control morning and 818.6 (238.5-1454.5) on the morning following the remifentanil infusion. Neither the number of NK cells ml(-1) (2.5 x 10(5) (1.4 x 10(5)-4.2 x 10(5)) vs 2.7 x 10(5) (1.1 x 10(5)-4.4 x 10(5))) nor the cytotoxicity per 1000 NK cells (KU 1000 NK cells(-1)) (3.0 (1.8-5.2) vs 2.9 (0.9-6.7)) changed between the control and remifentanil conditions. CONCLUSIONS An 8-h infusion of remifentanil did not affect NK cell activity in normal volunteers. This result differs from previous findings of morphine-induced NK cell activity suppression and fentanyl-induced NK cell activity enhancement in normal volunteers.

UI MeSH Term Description Entries
D007262 Infusions, Intravenous The long-term (minutes to hours) administration of a fluid into the vein through venipuncture, either by letting the fluid flow by gravity or by pumping it. Drip Infusions,Intravenous Drip,Intravenous Infusions,Drip Infusion,Drip, Intravenous,Infusion, Drip,Infusion, Intravenous,Infusions, Drip,Intravenous Infusion
D007694 Killer Cells, Natural Bone marrow-derived lymphocytes that possess cytotoxic properties, classically directed against transformed and virus-infected cells. Unlike T CELLS; and B CELLS; NK CELLS are not antigen specific. The cytotoxicity of natural killer cells is determined by the collective signaling of an array of inhibitory and stimulatory CELL SURFACE RECEPTORS. A subset of T-LYMPHOCYTES referred to as NATURAL KILLER T CELLS shares some of the properties of this cell type. NK Cells,Natural Killer Cells,Cell, NK,Cell, Natural Killer,Cells, NK,Cells, Natural Killer,Killer Cell, Natural,NK Cell,Natural Killer Cell
D008297 Male Males
D010880 Piperidines A family of hexahydropyridines.
D012119 Respiration The act of breathing with the LUNGS, consisting of INHALATION, or the taking into the lungs of the ambient air, and of EXHALATION, or the expelling of the modified air which contains more CARBON DIOXIDE than the air taken in (Blakiston's Gould Medical Dictionary, 4th ed.). This does not include tissue respiration ( Breathing
D003602 Cytotoxicity, Immunologic The phenomenon of target cell destruction by immunologically active effector cells. It may be brought about directly by sensitized T-lymphocytes or by lymphoid or myeloid "killer" cells, or it may be mediated by cytotoxic antibody, cytotoxic factor released by lymphoid cells, or complement. Tumoricidal Activity, Immunologic,Immunologic Cytotoxicity,Immunologic Tumoricidal Activities,Immunologic Tumoricidal Activity,Tumoricidal Activities, Immunologic
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000077208 Remifentanil A piperidine-propionate derivative and opioid analgesic structurally related to FENTANYL. It functions as a short-acting MU OPIOID RECEPTOR agonist, and is used as an analgesic during induction or maintenance of general anesthesia, following surgery, during childbirth, and in mechanically ventilated patients under intensive care. 3-(4-Methoxycarbonyl-4-((1-oxopropyl)phenylamino)-1-piperidine)propanoic Acid Methyl Ester,GI 87084B,GI-87084B,GI87084B,Remifentanil Hydrochloride,Remifentanil Monohydrochloride,Ultiva
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults

Related Publications

A J Cronin, and N M Aucutt-Walter, and T Budinetz, and C P Bonafide, and N A DiVittore, and V Gordin, and H G Schuler, and R H Bonneau
High-dose remifentanil does not impair cerebrovascular carbon dioxide reactivity in healthy male volunteers.
October 2003, Anesthesiology,
A J Cronin, and N M Aucutt-Walter, and T Budinetz, and C P Bonafide, and N A DiVittore, and V Gordin, and H G Schuler, and R H Bonneau
Sunitinib does not impair natural killer cell function in patients with renal cell carcinoma.
July 2017, Oncology letters,
A J Cronin, and N M Aucutt-Walter, and T Budinetz, and C P Bonafide, and N A DiVittore, and V Gordin, and H G Schuler, and R H Bonneau
Natural killer cell activity during cortisol and adrenaline infusion in healthy volunteers.
December 1987, European journal of clinical investigation,
A J Cronin, and N M Aucutt-Walter, and T Budinetz, and C P Bonafide, and N A DiVittore, and V Gordin, and H G Schuler, and R H Bonneau
Remifentanil does not impair left ventricular systolic and diastolic function in young healthy patients.
April 2011, British journal of anaesthesia,
A J Cronin, and N M Aucutt-Walter, and T Budinetz, and C P Bonafide, and N A DiVittore, and V Gordin, and H G Schuler, and R H Bonneau
In-vivo administration of histone deacetylase inhibitors does not impair natural killer cell function in HIV+ individuals.
March 2019, AIDS (London, England),
A J Cronin, and N M Aucutt-Walter, and T Budinetz, and C P Bonafide, and N A DiVittore, and V Gordin, and H G Schuler, and R H Bonneau
Biostin (RU-41740) does not impair antipyrine metabolism in healthy volunteers.
September 1989, Methods and findings in experimental and clinical pharmacology,
A J Cronin, and N M Aucutt-Walter, and T Budinetz, and C P Bonafide, and N A DiVittore, and V Gordin, and H G Schuler, and R H Bonneau
Hyperuricaemia does not impair cardiovascular function in healthy adults.
February 2004, Heart (British Cardiac Society),
A J Cronin, and N M Aucutt-Walter, and T Budinetz, and C P Bonafide, and N A DiVittore, and V Gordin, and H G Schuler, and R H Bonneau
Ultra-low dose interleukin-2 promotes immune-modulating function of regulatory T cells and natural killer cells in healthy volunteers.
July 2014, Molecular therapy : the journal of the American Society of Gene Therapy,
A J Cronin, and N M Aucutt-Walter, and T Budinetz, and C P Bonafide, and N A DiVittore, and V Gordin, and H G Schuler, and R H Bonneau
Human adipose-derived stem cells impair natural killer cell function and exhibit low susceptibility to natural killer-mediated lysis.
May 2012, Stem cells and development,
A J Cronin, and N M Aucutt-Walter, and T Budinetz, and C P Bonafide, and N A DiVittore, and V Gordin, and H G Schuler, and R H Bonneau
Electroencephalographic approximate entropy changes in healthy volunteers during remifentanil infusion.
May 2006, Anesthesiology,
Copied contents to your clipboard!