Solitary plasmacytoma of the mandible in a renal transplant recipient. 2003

J H Yoon, and J I Yook, and H J Kim, and I H Cha, and W I Yang, and J Kim
Department of Oral Pathology, College of Dentistry, Chosun University, Gwangju, Korea.

A solitary plasmacytoma occurring in the mandible of a 15-year-old Korean male 6 years after renal transplantation is reported. The tumour presented as a hyperplastic gingival overgrowth in the right madibular molar area. Histology and immunohistochemistry revealed plasmacytoma and monoclonality of the kappa chain and IgG. In situ hybridization for Epstein-Barr virus encoded RNA (EBER) showed positive signals in the tumour cells. The tumour regressed after reducing the immunosuppressive agents with concurrent radiotherapy. The patient remains in a stable condition with normal renal functions after 7 years without recurrence. This case confirms that Epstein-Barr virus associated B-lymphoproliferative disorders are still a major complication of immunosuppression.

UI MeSH Term Description Entries
D007166 Immunosuppressive Agents Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging. Immunosuppressant,Immunosuppressive Agent,Immunosuppressants,Agent, Immunosuppressive,Agents, Immunosuppressive
D008297 Male Males
D008339 Mandibular Neoplasms Tumors or cancer of the MANDIBLE. Mandibular Neoplasm,Neoplasm, Mandibular,Neoplasms, Mandibular
D010954 Plasmacytoma Any discrete, presumably solitary, mass of neoplastic PLASMA CELLS either in BONE MARROW or various extramedullary sites. Plasma Cell Tumor,Plasmocytoma,Plasma Cell Tumors,Plasmacytomas,Plasmocytomas,Tumor, Plasma Cell,Tumors, Plasma Cell
D004854 Herpesvirus 4, Human The type species of LYMPHOCRYPTOVIRUS, subfamily GAMMAHERPESVIRINAE, infecting B-cells in humans. It is thought to be the causative agent of INFECTIOUS MONONUCLEOSIS and is strongly associated with oral hairy leukoplakia (LEUKOPLAKIA, HAIRY;), BURKITT LYMPHOMA; and other malignancies. Burkitt Herpesvirus,Burkitt Lymphoma Virus,E-B Virus,EBV,Epstein-Barr Virus,Human Herpesvirus 4,Infectious Mononucleosis Virus,Burkitt's Lymphoma Virus,HHV-4,Herpesvirus 4 (gamma), Human,Burkitts Lymphoma Virus,E B Virus,E-B Viruses,Epstein Barr Virus,Herpesvirus, Burkitt,Infectious Mononucleosis Viruses,Lymphoma Virus, Burkitt,Mononucleosis Virus, Infectious,Mononucleosis Viruses, Infectious
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000293 Adolescent A person 13 to 18 years of age. Adolescence,Youth,Adolescents,Adolescents, Female,Adolescents, Male,Teenagers,Teens,Adolescent, Female,Adolescent, Male,Female Adolescent,Female Adolescents,Male Adolescent,Male Adolescents,Teen,Teenager,Youths
D016030 Kidney Transplantation The transference of a kidney from one human or animal to another. Grafting, Kidney,Renal Transplantation,Transplantation, Kidney,Transplantation, Renal,Kidney Grafting,Kidney Transplantations,Renal Transplantations,Transplantations, Kidney,Transplantations, Renal
D017403 In Situ Hybridization A technique that localizes specific nucleic acid sequences within intact chromosomes, eukaryotic cells, or bacterial cells through the use of specific nucleic acid-labeled probes. Hybridization in Situ,Hybridization, In Situ,Hybridizations, In Situ,In Situ Hybridizations
D020031 Epstein-Barr Virus Infections Infection with human herpesvirus 4 (HERPESVIRUS 4, HUMAN); which may facilitate the development of various lymphoproliferative disorders. These include BURKITT LYMPHOMA (African type), INFECTIOUS MONONUCLEOSIS, and oral hairy leukoplakia (LEUKOPLAKIA, HAIRY). EBV Infections,Epstein-Barr Virus Infection,Herpesvirus 4 Infections, Human,Human Herpes Virus 4 Infections,Human Herpesvirus 4 Infections,Infections, EBV,Infections, Epstein-Barr Virus,EBV Infection,Epstein Barr Virus Infection,Epstein Barr Virus Infections,Infection, EBV,Infection, Epstein-Barr Virus,Virus Infection, Epstein-Barr,Virus Infections, Epstein-Barr

Related Publications

J H Yoon, and J I Yook, and H J Kim, and I H Cha, and W I Yang, and J Kim
April 2005, International journal of hematology,
J H Yoon, and J I Yook, and H J Kim, and I H Cha, and W I Yang, and J Kim
December 1989, To Helleniko periodiko gia stomatike & gnathoprosopike cheirourgike,
J H Yoon, and J I Yook, and H J Kim, and I H Cha, and W I Yang, and J Kim
January 1972, Rassegna internazionale di stomatologia pratica,
J H Yoon, and J I Yook, and H J Kim, and I H Cha, and W I Yang, and J Kim
August 2023, Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi,
J H Yoon, and J I Yook, and H J Kim, and I H Cha, and W I Yang, and J Kim
May 2022, JAAD case reports,
J H Yoon, and J I Yook, and H J Kim, and I H Cha, and W I Yang, and J Kim
July 1979, Acta pathologica japonica,
J H Yoon, and J I Yook, and H J Kim, and I H Cha, and W I Yang, and J Kim
March 2023, Journal of dentistry (Shiraz, Iran),
J H Yoon, and J I Yook, and H J Kim, and I H Cha, and W I Yang, and J Kim
July 2021, International journal of surgery case reports,
J H Yoon, and J I Yook, and H J Kim, and I H Cha, and W I Yang, and J Kim
June 2013, Journal of international oral health : JIOH,
J H Yoon, and J I Yook, and H J Kim, and I H Cha, and W I Yang, and J Kim
January 2024, Radiology case reports,
Copied contents to your clipboard!