Polyion complex micelles entrapping cationic dendrimer porphyrin: effective photosensitizer for photodynamic therapy of cancer. 2003

Guo-Dong Zhang, and Atsushi Harada, and Nobuhiro Nishiyama, and Dong-Lin Jiang, and Hiroyuki Koyama, and Takuzo Aida, and Kazunori Kataoka
Department of Materials Science and Engineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113-8656, Japan.

Photosensitizers play a crucial role in the photodynamic therapy (PDT) of cancer. In this study, a third-generation aryl ether dendrimer porphyrin with 32 primary amine groups on the periphery, [NH2CH2CH2NHCO]32DPZn, and pH-sensitive, polyion complex micelles (PIC) composed of the porphyrin dendrimer and PEG-b-poly(aspartic acid), were evaluated as new photosensitizers (PSs) for PDT in the Lewis Lung Carcinoma (LLC) cell line. The preliminary photophysical characteristics of [NH2CH2CH2NHCO]32DPZn and the corresponding micelles were investigated. Electrostatic assembly resulted in a red-shift of the Soret peak of the porphyrin core and the enhanced fluorescence. Compared to the dendrimer porphyrin [NH2CH2CH2NHCO]32DPZn, relatively low cellular uptake of dendrimer porphyrin [NH2CH2CH2NHCO]32DPZn incorporated in the PIC micelle was observed, yet the latter exhibited enhanced photodynamic efficacy on the LLC cell line. Importantly, the use of PIC micelles as a delivery system reduced the dark toxicity of the cationic dendrimer porphyrin, probably due to the biocompatible PEG shell of the micelles.

UI MeSH Term Description Entries
D008665 Metalloporphyrins Porphyrins which are combined with a metal ion. The metal is bound equally to all four nitrogen atoms of the pyrrole rings. They possess characteristic absorption spectra which can be utilized for identification or quantitative estimation of porphyrins and porphyrin-bound compounds. Metalloporphyrin
D008823 Micelles Particles consisting of aggregates of molecules held loosely together by secondary bonds. The surface of micelles are usually comprised of amphiphatic compounds that are oriented in a way that minimizes the energy of interaction between the micelle and its environment. Liquids that contain large numbers of suspended micelles are referred to as EMULSIONS. Micelle
D009369 Neoplasms New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms. Benign Neoplasm,Cancer,Malignant Neoplasm,Tumor,Tumors,Benign Neoplasms,Malignancy,Malignant Neoplasms,Neoplasia,Neoplasm,Neoplasms, Benign,Cancers,Malignancies,Neoplasias,Neoplasm, Benign,Neoplasm, Malignant,Neoplasms, Malignant
D010647 Phenyl Ethers Ethers that are linked to a benzene ring structure. Diphenyl Oxide,Diphenyl Oxides,Diphenyl Ethers,Ethers, Diphenyl,Ethers, Phenyl,Oxide, Diphenyl,Oxides, Diphenyl
D010778 Photochemotherapy Therapy using oral or topical photosensitizing agents with subsequent exposure to light. Blue Light Photodynamic Therapy,Photodynamic Therapy,Red Light PDT,Red Light Photodynamic Therapy,Therapy, Photodynamic,Light PDT, Red,PDT, Red Light,Photochemotherapies,Photodynamic Therapies,Therapies, Photodynamic
D010789 Phototherapy Treatment of disease by exposure to light, especially by variously concentrated light rays or specific wavelengths. Blue Light Therapy,Blue-light Therapy,Light Therapy,Photoradiation Therapy,Red Light Phototherapy,Therapy, Photoradiation,Blue Light Therapies,Blue-light Therapies,Light Phototherapies, Red,Light Phototherapy, Red,Light Therapies,Light Therapies, Blue,Light Therapy, Blue,Photoradiation Therapies,Phototherapies,Phototherapies, Red Light,Phototherapy, Red Light,Red Light Phototherapies,Therapies, Blue Light,Therapies, Blue-light,Therapies, Light,Therapies, Photoradiation,Therapy, Blue Light,Therapy, Blue-light,Therapy, Light
D011092 Polyethylene Glycols Polymers of ETHYLENE OXIDE and water, and their ethers. They vary in consistency from liquid to solid depending on the molecular weight indicated by a number following the name. They are used as SURFACTANTS, dispersing agents, solvents, ointment and suppository bases, vehicles, and tablet excipients. Some specific groups are NONOXYNOLS, OCTOXYNOLS, and POLOXAMERS. Macrogols,Polyoxyethylenes,Carbowax,Macrogol,Polyethylene Glycol,Polyethylene Oxide,Polyethyleneoxide,Polyglycol,Glycol, Polyethylene,Glycols, Polyethylene,Oxide, Polyethylene,Oxides, Polyethylene,Polyethylene Oxides,Polyethyleneoxides,Polyglycols,Polyoxyethylene
D011108 Polymers Compounds formed by the joining of smaller, usually repeating, units linked by covalent bonds. These compounds often form large macromolecules (e.g., BIOPOLYMERS; PLASTICS). Polymer
D011166 Porphyrins A group of compounds containing the porphin structure, four pyrrole rings connected by methine bridges in a cyclic configuration to which a variety of side chains are attached. The nature of the side chain is indicated by a prefix, as uroporphyrin, hematoporphyrin, etc. The porphyrins, in combination with iron, form the heme component in biologically significant compounds such as hemoglobin and myoglobin. Porphyrin
D011506 Proteins Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein. Gene Products, Protein,Gene Proteins,Protein,Protein Gene Products,Proteins, Gene

Related Publications

Guo-Dong Zhang, and Atsushi Harada, and Nobuhiro Nishiyama, and Dong-Lin Jiang, and Hiroyuki Koyama, and Takuzo Aida, and Kazunori Kataoka
July 2022, Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition,
Guo-Dong Zhang, and Atsushi Harada, and Nobuhiro Nishiyama, and Dong-Lin Jiang, and Hiroyuki Koyama, and Takuzo Aida, and Kazunori Kataoka
November 2011, Journal of controlled release : official journal of the Controlled Release Society,
Guo-Dong Zhang, and Atsushi Harada, and Nobuhiro Nishiyama, and Dong-Lin Jiang, and Hiroyuki Koyama, and Takuzo Aida, and Kazunori Kataoka
April 2009, Advanced drug delivery reviews,
Guo-Dong Zhang, and Atsushi Harada, and Nobuhiro Nishiyama, and Dong-Lin Jiang, and Hiroyuki Koyama, and Takuzo Aida, and Kazunori Kataoka
February 2021, Biomacromolecules,
Guo-Dong Zhang, and Atsushi Harada, and Nobuhiro Nishiyama, and Dong-Lin Jiang, and Hiroyuki Koyama, and Takuzo Aida, and Kazunori Kataoka
June 2006, Journal of controlled release : official journal of the Controlled Release Society,
Guo-Dong Zhang, and Atsushi Harada, and Nobuhiro Nishiyama, and Dong-Lin Jiang, and Hiroyuki Koyama, and Takuzo Aida, and Kazunori Kataoka
August 2021, Pharmaceutics,
Guo-Dong Zhang, and Atsushi Harada, and Nobuhiro Nishiyama, and Dong-Lin Jiang, and Hiroyuki Koyama, and Takuzo Aida, and Kazunori Kataoka
May 2019, Organic & biomolecular chemistry,
Guo-Dong Zhang, and Atsushi Harada, and Nobuhiro Nishiyama, and Dong-Lin Jiang, and Hiroyuki Koyama, and Takuzo Aida, and Kazunori Kataoka
January 2020, Organic & biomolecular chemistry,
Guo-Dong Zhang, and Atsushi Harada, and Nobuhiro Nishiyama, and Dong-Lin Jiang, and Hiroyuki Koyama, and Takuzo Aida, and Kazunori Kataoka
February 2009, Journal of controlled release : official journal of the Controlled Release Society,
Guo-Dong Zhang, and Atsushi Harada, and Nobuhiro Nishiyama, and Dong-Lin Jiang, and Hiroyuki Koyama, and Takuzo Aida, and Kazunori Kataoka
November 2011, Journal of controlled release : official journal of the Controlled Release Society,
Copied contents to your clipboard!