BIOMAT Database Logo BIOMAT Database Logo

Urinary metabolites of nobiletin orally administered to rats. 2003

Takaaki Yasuda, and Yukako Yoshimura, and Hisako Yabuki, and Takahiro Nakazawa, and Keisuke Ohsawa, and Yoshihiro Mimaki, and Yutaka Sashida
Department of Phytochemistry, Tohoku Pharmaceutical University, Sendai, Miyagi, Japan.

During the course of our systematic investigation of the metabolism of flavonoids, the polymethoxyflavone nobiletin, occurring in the fruits of Citrus depressa, was orally administered to rats. The urinary metabolites were separated and identified by three-dimensional HPLC equipped with a photodiode array detector and the structure was determined by spectroscopic methods to be 4'-hydroxy-3',5,6,7,8-pentamethoxyflavone (1).

UI MeSH Term Description Entries
D008297 Male Males
D005419 Flavonoids A group of phenyl benzopyrans named for having structures like FLAVONES. 2-Phenyl-Benzopyran,2-Phenyl-Chromene,Bioflavonoid,Bioflavonoids,Flavonoid,2-Phenyl-Benzopyrans,2-Phenyl-Chromenes,2 Phenyl Benzopyran,2 Phenyl Benzopyrans,2 Phenyl Chromene,2 Phenyl Chromenes
D000284 Administration, Oral The giving of drugs, chemicals, or other substances by mouth. Drug Administration, Oral,Administration, Oral Drug,Oral Administration,Oral Drug Administration,Administrations, Oral,Administrations, Oral Drug,Drug Administrations, Oral,Oral Administrations,Oral Drug Administrations
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D001711 Biotransformation The chemical alteration of an exogenous substance by or in a biological system. The alteration may inactivate the compound or it may result in the production of an active metabolite of an inactive parent compound. The alterations may be divided into METABOLIC DETOXICATION, PHASE I and METABOLIC DETOXICATION, PHASE II.
D017207 Rats, Sprague-Dawley A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company. Holtzman Rat,Rats, Holtzman,Sprague-Dawley Rat,Rats, Sprague Dawley,Holtzman Rats,Rat, Holtzman,Rat, Sprague-Dawley,Sprague Dawley Rat,Sprague Dawley Rats,Sprague-Dawley Rats
D047309 Flavones A group of 4-keto-FLAVONOIDS. 2-Phenyl-2-Ene-Benzopyran-4-One Compounds
D051381 Rats The common name for the genus Rattus. Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus

Related Publications

Takaaki Yasuda, and Yukako Yoshimura, and Hisako Yabuki, and Takahiro Nakazawa, and Keisuke Ohsawa, and Yoshihiro Mimaki, and Yutaka Sashida
Urinary metabolites of genistein administered orally to rats.
November 2001, Chemical & pharmaceutical bulletin,
Takaaki Yasuda, and Yukako Yoshimura, and Hisako Yabuki, and Takahiro Nakazawa, and Keisuke Ohsawa, and Yoshihiro Mimaki, and Yutaka Sashida
Urinary metabolites of daidzin orally administered in rats.
September 1998, Biological & pharmaceutical bulletin,
Takaaki Yasuda, and Yukako Yoshimura, and Hisako Yabuki, and Takahiro Nakazawa, and Keisuke Ohsawa, and Yoshihiro Mimaki, and Yutaka Sashida
Monodemethylated Metabolites of Orally Administered Nobiletin: Identification and Quantitation in Rat Plasma and Tissues.
July 2023, Journal of agricultural and food chemistry,
Takaaki Yasuda, and Yukako Yoshimura, and Hisako Yabuki, and Takahiro Nakazawa, and Keisuke Ohsawa, and Yoshihiro Mimaki, and Yutaka Sashida
Urinary excretion of N-nitrosodiethanolamine administered orally to rats.
April 1978, Cancer letters,
Takaaki Yasuda, and Yukako Yoshimura, and Hisako Yabuki, and Takahiro Nakazawa, and Keisuke Ohsawa, and Yoshihiro Mimaki, and Yutaka Sashida
Identification of urinary metabolites of orally administered N,N-dimethyl-p-toluidine in male F344 rats.
May 2007, Journal of toxicology and environmental health. Part A,
Takaaki Yasuda, and Yukako Yoshimura, and Hisako Yabuki, and Takahiro Nakazawa, and Keisuke Ohsawa, and Yoshihiro Mimaki, and Yutaka Sashida
Plasma and urinary metabolites of progesterone-4-C14 administered orally or subcutaneously to rabbits.
November 1965, Steroids,
Takaaki Yasuda, and Yukako Yoshimura, and Hisako Yabuki, and Takahiro Nakazawa, and Keisuke Ohsawa, and Yoshihiro Mimaki, and Yutaka Sashida
Metabolites of orally administered Perilla frutescens extract in rats and humans.
January 2000, Biological & pharmaceutical bulletin,
Takaaki Yasuda, and Yukako Yoshimura, and Hisako Yabuki, and Takahiro Nakazawa, and Keisuke Ohsawa, and Yoshihiro Mimaki, and Yutaka Sashida
Identification and quantification of metabolites of orally administered naringenin chalcone in rats.
July 2009, Journal of agricultural and food chemistry,
Takaaki Yasuda, and Yukako Yoshimura, and Hisako Yabuki, and Takahiro Nakazawa, and Keisuke Ohsawa, and Yoshihiro Mimaki, and Yutaka Sashida
Pharmacokinetics of Paradol Analogues Orally Administered to Rats.
March 2016, Journal of agricultural and food chemistry,
Takaaki Yasuda, and Yukako Yoshimura, and Hisako Yabuki, and Takahiro Nakazawa, and Keisuke Ohsawa, and Yoshihiro Mimaki, and Yutaka Sashida
Metabolic fate of fraxin administered orally to rats.
May 2006, Journal of natural products,
Copied contents to your clipboard!