Stability of cisplatin in ethylene vinylacetate portable infusion-pump reservoirs. 1992

E Rochard, and D Barthes, and P Courtois
Institut du Médicament, Faculté de Médecine et de Pharmacie, Poitiers, France.

The stability of cisplatin in admixture stored in portable pump reservoirs was investigated. Admixtures containing 0.9 or 0.5 mg/ml cisplatin in 0.9% sodium chloride injection were placed in 80-ml ethylene vinylacetate (EVA) drug reservoirs protected from light and 1-ml quantities were withdrawn immediately after preparation and after storage for 1, 2, 3, 4, 7, 14, 28 days at +22 or +35 degrees C. Three samples for each condition from each admixture were tested for drug concentration using a stability-indicating high-performance liquid chromatographic method. No colour change or precipitation was observed, and pH values were stable for the duration of the study. Loss of water through the reservoirs was substantial only when stored at +35 degrees C for 28 days. Cisplatin is stable in the infusion fluid used for 28 days under all the storage conditions considered.

UI MeSH Term Description Entries
D007260 Infusion Pumps Fluid propulsion systems driven mechanically, electrically, or osmotically that are used to inject (or infuse) over time agents into a patient or experimental animal; used routinely in hospitals to maintain a patent intravenous line, to administer antineoplastic agents and other drugs in thromboembolism, heart disease, diabetes mellitus (INSULIN INFUSION SYSTEMS is also available), and other disorders. Drug Infusion Systems,Infusion Pump,Infusion Pumps, External,Infusors,Intravenous Drug Delivery System,Intravenous Drug Delivery Systems,Perfusion Pumps,Pumps, Infusion,Drug Infusion System,External Infusion Pump,External Infusion Pumps,Infusion Pump, External,Infusion System, Drug,Infusion Systems, Drug,Infusor,Perfusion Pump,Pump, External Infusion,Pump, Infusion,Pump, Perfusion,Pumps, External Infusion,Pumps, Perfusion,System, Drug Infusion,Systems, Drug Infusion
D002945 Cisplatin An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle. Platinum Diamminodichloride,cis-Diamminedichloroplatinum(II),cis-Dichlorodiammineplatinum(II),Biocisplatinum,Dichlorodiammineplatinum,NSC-119875,Platidiam,Platino,Platinol,cis-Diamminedichloroplatinum,cis-Platinum,Diamminodichloride, Platinum,cis Diamminedichloroplatinum,cis Platinum
D004355 Drug Stability The chemical and physical integrity of a pharmaceutical product. Drug Shelf Life,Drugs Shelf Lives,Shelf Life, Drugs,Drug Stabilities,Drugs Shelf Life,Drugs Shelf Live,Life, Drugs Shelf,Shelf Life, Drug,Shelf Live, Drugs,Shelf Lives, Drugs
D004356 Drug Storage The process of keeping pharmaceutical products in an appropriate location. Drug Storages,Storage, Drug,Storages, Drug
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D014753 Vinyl Compounds Compounds containing the vinyl (-C Compounds, Vinyl

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