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Muscle protein turnover and amino acid (AA) exchange were studied in 4 patients with chronic renal failure (CRF) and in 5 controls in the postabsorptive state by using the forearm perfusion method together with the systemic infusion of 3H-Phe. In CRF patients muscle protein breakdown is increased and is associated with a parallel increase in protein synthesis. Protein breakdown is inversely related to arterial bicarbonate. Net proteolysis is unchanged. The release of total AA, glutamine and alanine is not different from controls, whereas the release of valine and leucine is reduced and serine uptake tends to be decreased. In conclusion, in postabsorptive patients with CRF, well before the uremic stage, an increased protein breakdown associated with metabolic acidosis takes place; net proteolysis is unaffected. Alterations in BCAA metabolism suggest the occurrence of increased BCAA degradation proceeding beyond the transamination step.
G Garibotto, and
R Russo, and
M R Sala, and
P Ancarani, and
C Robaudo, and
A Sofia, and
G Deferrari, and
A Tizianello
February 1999,
Nutrition (Burbank, Los Angeles County, Calif.),
G Garibotto, and
R Russo, and
M R Sala, and
P Ancarani, and
C Robaudo, and
A Sofia, and
G Deferrari, and
A Tizianello
January 2005,
Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation,
G Garibotto, and
R Russo, and
M R Sala, and
P Ancarani, and
C Robaudo, and
A Sofia, and
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A Tizianello
December 1997,
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G Garibotto, and
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C Robaudo, and
A Sofia, and
G Deferrari, and
A Tizianello
September 1990,
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G Garibotto, and
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A Tizianello
September 1978,
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G Garibotto, and
R Russo, and
M R Sala, and
P Ancarani, and
C Robaudo, and
A Sofia, and
G Deferrari, and
A Tizianello
January 2005,
Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation,
G Garibotto, and
R Russo, and
M R Sala, and
P Ancarani, and
C Robaudo, and
A Sofia, and
G Deferrari, and
A Tizianello
October 1987,
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G Garibotto, and
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A Tizianello
January 1990,
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G Garibotto, and
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P Ancarani, and
C Robaudo, and
A Sofia, and
G Deferrari, and
A Tizianello
December 1983,
Kidney international. Supplement,
G Garibotto, and
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A Tizianello
January 1989,
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