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Peripheral human T cells, isolated by sheep erythrocyte-rosette formation and density centrifugation, were highly cytotoxic to both Ab-coated autologous lymphocytes and antibody (Ab)-coated chicken erythrocytes when stimulated in mixed lymphocyte culture, but were not lytic when freshly purified, or when unstimulated in 6-day culture. Allosensitized T cells were shown to effect this activity by a specific effector-target cell interaction dependent on Ab, as indicated by: (a) induction of killing by Ab to target cells not lysed in the absence of Ab. (b) inhibition of Ab-dependent killing by aggregated Ig. The mechanism by which allosensitized T cells effect antibody-dependent cellular cytotoxicity is discussed.
R L Evans, and
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S F Schlossman
November 1974,
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R L Evans, and
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R L Evans, and
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R L Evans, and
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December 2021,
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R L Evans, and
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R L Evans, and
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R L Evans, and
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R L Evans, and
L Chess, and
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S F Schlossman
November 1978,
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R L Evans, and
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R L Evans, and
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