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Discovery of a novel bicycloproline P2 bearing peptidyl alpha-ketoamide LY514962 as HCV protease inhibitor. 2004
Yvonne Yip, and
Frantz Victor, and
Jason Lamar, and
Robert Johnson, and
Q May Wang, and
Donna Barket, and
John Glass, and
Ling Jin, and
Lifei Liu, and
Daryl Venable, and
Mark Wakulchik, and
Congping Xie, and
Beverly Heinz, and
Elcira Villarreal, and
Joe Colacino, and
Nathan Yumibe, and
Mark Tebbe, and
John Munroe, and
Shu-Hui Chen
Lilly Research Laboratory, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA.
We describe herein the design, syntheses and evaluation of a number of bicycloproline P2 bearing HCV protease inhibitors endowed with impressive enzyme potency, enzyme selectivity, cellular activity and favorable ADME profiles.
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