-transparent.png){kind=logo}
Seven families with translocations t(11; 22) identified at our Institute and analysis of the literature showed that the imbalance resulted from such translocations is always due to nondisjunction 3:1. Nondisjunction occurs more often in the 1st meiotic division, and is more rare in the second one. Expressed prezygotic selection against spermia with an additional chromosome greatly increases the risk of having an imbalanced child for the women-carriers as compared to men-carriers. The phenotype of the patients with +der(22)t(11; 22) is composed of the features characteristic for trisomy 22q (cleft lip and palate, preauricular papillomas and fistulas, rectal atresia or stenosis) and trisomy 11q (long philtrum with the upper lip hanging over, renal al; asia and hypoplasia). Diaphragmatic hernias are found to be common for the patients with +der(22)t(11; 22).
I V Lur'e, and
N V Rumiantseva, and
L V Podleshchuk, and
S I Kozlova, and
V D Kulak, and
I V Naumchik, and
L B Gorelik, and
T V Zolotukhina, and
M I Kuznetsov
October 1990,
American journal of medical genetics,
I V Lur'e, and
N V Rumiantseva, and
L V Podleshchuk, and
S I Kozlova, and
V D Kulak, and
I V Naumchik, and
L B Gorelik, and
T V Zolotukhina, and
M I Kuznetsov
September 1993,
Prenatal diagnosis,
I V Lur'e, and
N V Rumiantseva, and
L V Podleshchuk, and
S I Kozlova, and
V D Kulak, and
I V Naumchik, and
L B Gorelik, and
T V Zolotukhina, and
M I Kuznetsov
January 1980,
Human genetics,
I V Lur'e, and
N V Rumiantseva, and
L V Podleshchuk, and
S I Kozlova, and
V D Kulak, and
I V Naumchik, and
L B Gorelik, and
T V Zolotukhina, and
M I Kuznetsov
May 1994,
American journal of human genetics,
I V Lur'e, and
N V Rumiantseva, and
L V Podleshchuk, and
S I Kozlova, and
V D Kulak, and
I V Naumchik, and
L B Gorelik, and
T V Zolotukhina, and
M I Kuznetsov
January 1983,
Human genetics,
I V Lur'e, and
N V Rumiantseva, and
L V Podleshchuk, and
S I Kozlova, and
V D Kulak, and
I V Naumchik, and
L B Gorelik, and
T V Zolotukhina, and
M I Kuznetsov
September 1981,
Anales espanoles de pediatria,
I V Lur'e, and
N V Rumiantseva, and
L V Podleshchuk, and
S I Kozlova, and
V D Kulak, and
I V Naumchik, and
L B Gorelik, and
T V Zolotukhina, and
M I Kuznetsov
January 1992,
American journal of medical genetics,
I V Lur'e, and
N V Rumiantseva, and
L V Podleshchuk, and
S I Kozlova, and
V D Kulak, and
I V Naumchik, and
L B Gorelik, and
T V Zolotukhina, and
M I Kuznetsov
February 1993,
Prenatal diagnosis,
I V Lur'e, and
N V Rumiantseva, and
L V Podleshchuk, and
S I Kozlova, and
V D Kulak, and
I V Naumchik, and
L B Gorelik, and
T V Zolotukhina, and
M I Kuznetsov
February 1992,
Human genetics,
I V Lur'e, and
N V Rumiantseva, and
L V Podleshchuk, and
S I Kozlova, and
V D Kulak, and
I V Naumchik, and
L B Gorelik, and
T V Zolotukhina, and
M I Kuznetsov
October 1989,
Human genetics,
