-transparent.png){kind=logo}
Presynaptic as well as postsynaptic adrenergic regulation abnormalities are reported in symptomatic patients with mitral valve prolapse. This study was undertaken to evaluate presynaptic sympathetic supply by m-[123I]iodobenzylguanidine scintigraphy in 17 preselected patients with mitral valve prolapse and symptoms suggestive of hyperadrenergic dysautonomia as compared to normal scintigraphic findings. Mitral valve prolapse was echocardiographically proven within the left parasternal long axis view. Percentual activity of m-[123I]iodobenzylguanidine in 33 sectors of all oblique slices along the short axis was calculated relative to the maximal uptake, set at 100%. In general, no significant differences of mean values of sectoral quantitative uptake of m-[123I]iodobenzylguanidine were detectable between patients and the control group. Only in two sectors of the basal anterolateral region P values < 0.01 were present. Thus, using m-[123I]iodobenzylguanidine scintigraphy as marker of cardiac adrenergic supply, no evidence of altered presynaptic hyperadrenergic supply was present in patients with mitral valve prolapse. These findings suggest postsynaptic regulation abnormalities to be preponderant in this condition.
K H Henneke, and
G Pongratz, and
H Feistel, and
B Kunkel, and
F Wolf, and
K Bachmann
January 1987,
International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology,
K H Henneke, and
G Pongratz, and
H Feistel, and
B Kunkel, and
F Wolf, and
K Bachmann
May 1995,
Diabetes,
K H Henneke, and
G Pongratz, and
H Feistel, and
B Kunkel, and
F Wolf, and
K Bachmann
April 2024,
Autonomic neuroscience : basic & clinical,
K H Henneke, and
G Pongratz, and
H Feistel, and
B Kunkel, and
F Wolf, and
K Bachmann
January 2022,
Progress in cardiovascular diseases,
K H Henneke, and
G Pongratz, and
H Feistel, and
B Kunkel, and
F Wolf, and
K Bachmann
February 1990,
Anesthesia and analgesia,
K H Henneke, and
G Pongratz, and
H Feistel, and
B Kunkel, and
F Wolf, and
K Bachmann
February 2002,
Cardiac electrophysiology review,
K H Henneke, and
G Pongratz, and
H Feistel, and
B Kunkel, and
F Wolf, and
K Bachmann
April 2001,
Circulation,
K H Henneke, and
G Pongratz, and
H Feistel, and
B Kunkel, and
F Wolf, and
K Bachmann
January 2019,
Revista espanola de medicina nuclear e imagen molecular,
K H Henneke, and
G Pongratz, and
H Feistel, and
B Kunkel, and
F Wolf, and
K Bachmann
August 1987,
The American journal of medicine,
K H Henneke, and
G Pongratz, and
H Feistel, and
B Kunkel, and
F Wolf, and
K Bachmann
October 1983,
Journal of the American College of Cardiology,
