[Nutritional status and Alzheimer's disease: preliminary results of the REAL.FR study]. 2003

P Brocker, and T Benhamidat, and M Benoit, and P Staccini, and C Bertogliati, and O Guérin, and L Lechowski, and P H Robert
Centre mémoire du CHU de Nice, France. brocker.p@chu-nice.fr

Weight loss is common in elderly people with dementia, particularly those with Alzheimer' disease (AD), and feeding difficulties are major issues in their care in the later stages of the disease. In this study (REAL FR for Réseau sur la maladie d'Alzheimer Français) we prospectively used the Mini Nutritional Assessment (MNA) to examine the nutritional status of 479 subjects. Three groups of patients were studied: group 1 = 22 patients with undernutrition (MNA = 17), group 2 = 166 patients with risk of undernutrition (17 < MNA < 24), and group 3 = 291 patients without undernutrition (MNA = 24). Correlations with behavioral and psychological signs and symptoms of dementia (Neuropsychiatric Inventory NPI), with caregiver distress (Zarit), and with the Mini Mental State Examination (MMSE) were studied. Undernutrition is more frequently associated with low MMSE (p < 0.001), high behavioural disturbances (p < 0.001) and high distress of caregivers (p < 0.001). Risk of undernutrition is also associated with NPI (p < 0.001) and Zarit (p < 0.001). These first results in a French cohort of patients with AD underline the importance of the evaluation of nutritional status and finally the follow-up of eating behavior, cognitive status and the quality of life of the caregivers.

UI MeSH Term Description Entries
D008297 Male Males
D009752 Nutritional Status State of the body in relation to the consumption and utilization of nutrients. Nutrition Status,Status, Nutrition,Status, Nutritional
D011446 Prospective Studies Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group. Prospective Study,Studies, Prospective,Study, Prospective
D005260 Female Females
D005602 France A country in western Europe bordered by the Atlantic Ocean, the English Channel, the Mediterranean Sea, and the countries of Belgium, Germany, Italy, Spain, Switzerland, the principalities of Andorra and Monaco, and by the duchy of Luxembourg. Its capital is Paris. Corsica,Saint Pierre and Miquelon,Miquelon and Saint Pierre,Miquelon and St. Pierre,St. Pierre and Miquelon
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000368 Aged A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available. Elderly
D000544 Alzheimer Disease A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57) Acute Confusional Senile Dementia,Alzheimer's Diseases,Dementia, Alzheimer Type,Dementia, Senile,Presenile Alzheimer Dementia,Senile Dementia, Alzheimer Type,Alzheimer Dementia,Alzheimer Disease, Early Onset,Alzheimer Disease, Late Onset,Alzheimer Sclerosis,Alzheimer Syndrome,Alzheimer Type Senile Dementia,Alzheimer's Disease,Alzheimer's Disease, Focal Onset,Alzheimer-Type Dementia (ATD),Dementia, Presenile,Dementia, Primary Senile Degenerative,Early Onset Alzheimer Disease,Familial Alzheimer Disease (FAD),Focal Onset Alzheimer's Disease,Late Onset Alzheimer Disease,Primary Senile Degenerative Dementia,Senile Dementia, Acute Confusional,Alzheimer Dementias,Alzheimer Disease, Familial (FAD),Alzheimer Diseases,Alzheimer Type Dementia,Alzheimer Type Dementia (ATD),Alzheimers Diseases,Dementia, Alzheimer,Dementia, Alzheimer-Type (ATD),Familial Alzheimer Diseases (FAD),Presenile Dementia,Sclerosis, Alzheimer,Senile Dementia

Related Publications

P Brocker, and T Benhamidat, and M Benoit, and P Staccini, and C Bertogliati, and O Guérin, and L Lechowski, and P H Robert
October 2003, La Revue de medecine interne,
P Brocker, and T Benhamidat, and M Benoit, and P Staccini, and C Bertogliati, and O Guérin, and L Lechowski, and P H Robert
January 2003, The journal of nutrition, health & aging,
P Brocker, and T Benhamidat, and M Benoit, and P Staccini, and C Bertogliati, and O Guérin, and L Lechowski, and P H Robert
January 2005, The journal of nutrition, health & aging,
P Brocker, and T Benhamidat, and M Benoit, and P Staccini, and C Bertogliati, and O Guérin, and L Lechowski, and P H Robert
February 2010, International psychogeriatrics,
P Brocker, and T Benhamidat, and M Benoit, and P Staccini, and C Bertogliati, and O Guérin, and L Lechowski, and P H Robert
October 2003, La Revue de medecine interne,
P Brocker, and T Benhamidat, and M Benoit, and P Staccini, and C Bertogliati, and O Guérin, and L Lechowski, and P H Robert
October 2003, La Revue de medecine interne,
P Brocker, and T Benhamidat, and M Benoit, and P Staccini, and C Bertogliati, and O Guérin, and L Lechowski, and P H Robert
October 2003, La Revue de medecine interne,
P Brocker, and T Benhamidat, and M Benoit, and P Staccini, and C Bertogliati, and O Guérin, and L Lechowski, and P H Robert
August 2011, The journal of nutrition, health & aging,
P Brocker, and T Benhamidat, and M Benoit, and P Staccini, and C Bertogliati, and O Guérin, and L Lechowski, and P H Robert
January 2009, Revista da Associacao Medica Brasileira (1992),
P Brocker, and T Benhamidat, and M Benoit, and P Staccini, and C Bertogliati, and O Guérin, and L Lechowski, and P H Robert
January 2005, The journal of nutrition, health & aging,
Copied contents to your clipboard!