Standard full-field electroretinography in healthy preterm infants. 2003

Adriana Berezovsky, and Nilva Simeren Bueno Moraes, and Steven Nusinowitz, and Solange Rios Salomão
Department of Ophthalmology, Federal University of São Paulo, São Paulo, SP, Brazil. aberezovsky@oftalmo.epm.br

The purpose of this study was to determine electroretinographic parameters according to the standard protocol from the International Society for Clinical Electrophysiology of Vision (ISCEV) in healthy preterm infants with normal fundus. Seventeen healthy preterm infants with normal fundus were recruited and divided in two age groups: 3-week group, nine infants with mean adjusted age at test = 2.67 +/- 0.92 weeks and 8-week group, eight infants with mean adjusted age at test = 7.92 +/- 1.72 weeks. Full-field ERGs were obtained with a Burian-Allen bipolar contact lens electrode from the anesthetized cornea in one eye, through a fully dilated pupil after 30 min of dark adaptation. The standard ISCEV protocol was used and the following responses were recorded: rod, maximal, oscillatory potentials, cone and 30 Hz flicker. Median values and 1st, 5th, 95th and 99th percentiles for amplitude and implicit time are described for both age groups. There was statistically larger amplitude for 30 Hz flicker (t = 2.191; p = 0.046) and for cone response (t = 2.307; p = 0.044) in the 8-week-old group. Statistically shorter implicit times were found in 8-week group for rod response (t = 3.219; p = 0.015), cone response (t = 2.839; p = 0.016) and flicker response (t = 3.326; p = 0.005). Shortening of implicit time was evident in the older group of preterms and this finding is consistent with other maturational studies confirming the anatomical and functional development of the photoreceptors. Medians and ranges between the 1st and 99th and the 5th and 95th percentiles can be used as a baseline for future comparisons with infants with ROP.

UI MeSH Term Description Entries
D007223 Infant A child between 1 and 23 months of age. Infants
D007231 Infant, Newborn An infant during the first 28 days after birth. Neonate,Newborns,Infants, Newborn,Neonates,Newborn,Newborn Infant,Newborn Infants
D007234 Infant, Premature A human infant born before 37 weeks of GESTATION. Neonatal Prematurity,Premature Infants,Preterm Infants,Infant, Preterm,Infants, Premature,Infants, Preterm,Premature Infant,Prematurity, Neonatal,Preterm Infant
D008297 Male Males
D009799 Ocular Physiological Phenomena Processes and properties of the EYE as a whole or of any of its parts. Ocular Physiologic Processes,Ocular Physiological Processes,Ocular Physiology,Eye Physiology,Ocular Physiologic Process,Ocular Physiological Concepts,Ocular Physiological Phenomenon,Ocular Physiological Process,Physiology of the Eye,Physiology, Ocular,Visual Physiology,Concept, Ocular Physiological,Concepts, Ocular Physiological,Ocular Physiological Concept,Phenomena, Ocular Physiological,Phenomenon, Ocular Physiological,Physiologic Process, Ocular,Physiologic Processes, Ocular,Physiological Concept, Ocular,Physiological Concepts, Ocular,Physiological Process, Ocular,Physiological Processes, Ocular,Physiology, Eye,Physiology, Visual,Process, Ocular Physiologic,Process, Ocular Physiological,Processes, Ocular Physiologic,Processes, Ocular Physiological
D009991 Oscillometry The measurement of frequency or oscillation changes. Oscillometries
D012160 Retina The ten-layered nervous tissue membrane of the eye. It is continuous with the OPTIC NERVE and receives images of external objects and transmits visual impulses to the brain. Its outer surface is in contact with the CHOROID and the inner surface with the VITREOUS BODY. The outer-most layer is pigmented, whereas the inner nine layers are transparent. Ora Serrata
D003623 Dark Adaptation Adjustment of the eyes under conditions of low light. The sensitivity of the eye to light is increased during dark adaptation. Scotopic Adaptation,Adaptation, Dark,Adaptation, Scotopic
D004596 Electroretinography Recording of electric potentials in the retina after stimulation by light. Electroretinographies
D005260 Female Females

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