Biomaterial Database

Optic neuritis in children--clinical and electrophysiological follow-up. 2003

M Tekavcic-Pompe, and B Stirn-Kranjc, and J Brecelj

Institute of Clinical Neurophysiology, University Medical Centre, Ljubljana, Slovenia. manca.tekavcic-pompe@guest.arnes.si

Optic neuritis (ON) in children usually presents with visual loss, relative afferent pupillary defect (RAPD), abnormal optic disc appearance, defects of visual field and colour vision, as well as with abnormalities of visual evoked potentials (VEP). Both, clinical and VEP parameters, improve after the attack; the time until recovery, however, is as yet unknown. The aim of this study was to follow-up children with ON for 1 year and to determine clinical and VEP recovery. Twelve children (six with bilateral, six with unilateral ON) were studied in the acute phase and systematically followed-up for 1 year. The results show that initially, visual acuity was diminished in all eyes, while after 1 year, in only 14% of them. Optic disc appearance was abnormal in 83.3% of the eyes in the acute phase, and in 85% after 1 year. At the disease onset RAPD could be detected in 67%, visual field defects in 58.5%, and colour vision defects in 50% of eyes, but none of these abnormalities persisted in any eye until the end of study. VEP were abnormal in 83% of eyes in the acute phase and in 56% at the final follow-up (at 6 or 12 months). VEP normalization, when occurred, was mostly observed during the first 6 months. Complete clinical and VEP recovery was observed in three children. Both, clinical and electrophysiological recovery in children with ON were relatively substantial and fast within the first year. VEP improvement may indicate better prognosis.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D009902	Optic Neuritis	Inflammation of the optic nerve. Commonly associated conditions include autoimmune disorders such as MULTIPLE SCLEROSIS, infections, and granulomatous diseases. Clinical features include retro-orbital pain that is aggravated by eye movement, loss of color vision, and contrast sensitivity that may progress to severe visual loss, an afferent pupillary defect (Marcus-Gunn pupil), and in some instances optic disc hyperemia and swelling. Inflammation may occur in the portion of the nerve within the globe (neuropapillitis or anterior optic neuritis) or the portion behind the globe (retrobulbar neuritis or posterior optic neuritis).	Neuropapillitis,Retrobulbar Neuritis,Anterior Optic Neuritis,Posterior Optic Neuritis,Anterior Optic Neuritides,Neuritides, Anterior Optic,Neuritides, Optic,Neuritides, Posterior Optic,Neuritides, Retrobulbar,Neuritis, Anterior Optic,Neuritis, Optic,Neuritis, Posterior Optic,Neuritis, Retrobulbar,Neuropapillitides,Optic Neuritides,Optic Neuritides, Anterior,Optic Neuritides, Posterior,Optic Neuritis, Anterior,Optic Neuritis, Posterior,Posterior Optic Neuritides,Retrobulbar Neuritides
D011446	Prospective Studies	Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.	Prospective Study,Studies, Prospective,Study, Prospective
D011681	Pupil Disorders	Conditions which affect the structure or function of the pupil of the eye, including disorders of innervation to the pupillary constrictor or dilator muscles, and disorders of pupillary reflexes.	Afferent Pupillary Defect,Efferent Pupillary Defect,Marcus-Gunn Pupil,Pupil Reaction Absent,Pupillary Functions, Abnormal,Deformed Pupil,Ectopic Pupil,Fixed Pupils,Keyhole Pupil,Non-Syphilitic Argyll-Robertson Pupil,Occluded Pupils,Pupil Malformations,Pupillary Anomaly,Pupillary Disorders,Pupillary Occlusion,Pupillary Paralysis,Pupillary Sector Paralysis,Pupillary Sphincter Rupture,Sector Pupil Palsy,Wernicke Hemianopic Pupil,Wernicke's Hemianopic Pupil,Abnormal Pupillary Function,Abnormal Pupillary Functions,Afferent Pupillary Defects,Anomalies, Pupillary,Anomaly, Pupillary,Argyll-Robertson Pupil, Non-Syphilitic,Deformed Pupils,Ectopic Pupils,Efferent Pupillary Defects,Fixed Pupil,Hemianopic Pupil, Wernicke,Hemianopic Pupil, Wernicke's,Keyhole Pupils,Malformation, Pupil,Malformations, Pupil,Marcus Gunn Pupil,Non Syphilitic Argyll Robertson Pupil,Occluded Pupil,Occlusion, Pupillary,Occlusions, Pupillary,Paralyses, Pupillary,Paralyses, Pupillary Sector,Paralysis, Pupillary,Paralysis, Pupillary Sector,Pupil Disorder,Pupil Malformation,Pupil, Deformed,Pupil, Ectopic,Pupil, Fixed,Pupil, Keyhole,Pupil, Marcus-Gunn,Pupil, Non-Syphilitic Argyll-Robertson,Pupil, Occluded,Pupil, Wernicke Hemianopic,Pupil, Wernicke's Hemianopic,Pupillary Anomalies,Pupillary Defect, Afferent,Pupillary Defect, Efferent,Pupillary Defects, Afferent,Pupillary Defects, Efferent,Pupillary Disorder,Pupillary Function, Abnormal,Pupillary Occlusions,Pupillary Paralyses,Pupillary Sector Paralyses,Pupillary Sphincter Ruptures,Pupils, Deformed,Pupils, Ectopic,Pupils, Fixed,Pupils, Keyhole,Pupils, Occluded,Reaction Absent, Pupil,Reaction Absents, Pupil,Rupture, Pupillary Sphincter,Ruptures, Pupillary Sphincter,Sector Paralyses, Pupillary,Sector Paralysis, Pupillary,Sphincter Rupture, Pupillary,Sphincter Ruptures, Pupillary,Wernickes Hemianopic Pupil
D002648	Child	A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL.	Children
D002675	Child, Preschool	A child between the ages of 2 and 5.	Children, Preschool,Preschool Child,Preschool Children
D003118	Color Perception	Mental processing of chromatic signals (COLOR VISION) from the eye by the VISUAL CORTEX where they are converted into symbolic representations. Color perception involves numerous neurons, and is influenced not only by the distribution of wavelengths from the viewed object, but also by its background color and brightness contrast at its boundary.	Color Perceptions,Perception, Color,Perceptions, Color
D005074	Evoked Potentials, Visual	The electric response evoked in the cerebral cortex by visual stimulation or stimulation of the visual pathways.	Visual Evoked Response,Evoked Potential, Visual,Evoked Response, Visual,Evoked Responses, Visual,Potential, Visual Evoked,Potentials, Visual Evoked,Response, Visual Evoked,Responses, Visual Evoked,Visual Evoked Potential,Visual Evoked Potentials,Visual Evoked Responses
D005260	Female		Females
D005500	Follow-Up Studies	Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.	Followup Studies,Follow Up Studies,Follow-Up Study,Followup Study,Studies, Follow-Up,Studies, Followup,Study, Follow-Up,Study, Followup