Immunohistochemical mucin expression of short-segment Barrett's esophagus. 2003

Soichiro Yamamoto, and Hiroshi Kijima, and Tadashi Hara, and Takahiro Kenmochi, and Yoshifumi Kise, and Hikaru Tanaka, and Osamu Chino, and Hideo Shimada, and Makiko Tanaka, and Sadaki Inokuchi, and Hiroyasu Makuuchi
Department of Surgery, Tokai University School of Medicine, Isehara, Kanagawa, Japan.

Barrett's mucosa consists of metaplastic columnar epithelium (specialized columnar epithelium) of the esophagus. Recently, "short-segment Barrett's esophagus (SSBE)" was proposed. In the present study, we examined immunohistochemical mucin expression and the Ki-67 labeling index (LI) of SSBE, in 5-15 mm lengths. All 27 SSBE cases showed gastric mucin (MUC5AC, HGM, MUC6). CD10 and MUC2, which were markers of intestinal phenotypes, were detected in 13 (48.1%) and 14 (51.9%) of the 27 SSBE cases. Ki-67 LI of SSBE positive cases for CD10 was 23.6 %, while that of SSBE negative cases for CD10 was 14.4 % (p < 0.05). SSBE cases were divided into two groups: one was gastric epithelium type with low Ki-67 LI, and the other was metaplastic epithelium with intestinal metaplasia and high Ki-67 LI. The latter group was suggested to be more important as a premalignant lesion of esophageal adenocarcinoma.

UI MeSH Term Description Entries
D007150 Immunohistochemistry Histochemical localization of immunoreactive substances using labeled antibodies as reagents. Immunocytochemistry,Immunogold Techniques,Immunogold-Silver Techniques,Immunohistocytochemistry,Immunolabeling Techniques,Immunogold Technics,Immunogold-Silver Technics,Immunolabeling Technics,Immunogold Silver Technics,Immunogold Silver Techniques,Immunogold Technic,Immunogold Technique,Immunogold-Silver Technic,Immunogold-Silver Technique,Immunolabeling Technic,Immunolabeling Technique,Technic, Immunogold,Technic, Immunogold-Silver,Technic, Immunolabeling,Technics, Immunogold,Technics, Immunogold-Silver,Technics, Immunolabeling,Technique, Immunogold,Technique, Immunogold-Silver,Technique, Immunolabeling,Techniques, Immunogold,Techniques, Immunogold-Silver,Techniques, Immunolabeling
D007413 Intestinal Mucosa Lining of the INTESTINES, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. In the SMALL INTESTINE, the mucosa is characterized by a series of folds and abundance of absorptive cells (ENTEROCYTES) with MICROVILLI. Intestinal Epithelium,Intestinal Glands,Epithelium, Intestinal,Gland, Intestinal,Glands, Intestinal,Intestinal Gland,Mucosa, Intestinal
D008679 Metaplasia A condition in which there is a change of one adult cell type to another similar adult cell type.
D009077 Mucins High molecular weight mucoproteins that protect the surface of EPITHELIAL CELLS by providing a barrier to particulate matter and microorganisms. Membrane-anchored mucins may have additional roles concerned with protein interactions at the cell surface. Mucin
D005753 Gastric Mucosa Lining of the STOMACH, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. The surface cells produce MUCUS that protects the stomach from attack by digestive acid and enzymes. When the epithelium invaginates into the LAMINA PROPRIA at various region of the stomach (CARDIA; GASTRIC FUNDUS; and PYLORUS), different tubular gastric glands are formed. These glands consist of cells that secrete mucus, enzymes, HYDROCHLORIC ACID, or hormones. Cardiac Glands,Gastric Glands,Pyloric Glands,Cardiac Gland,Gastric Gland,Gastric Mucosas,Gland, Cardiac,Gland, Gastric,Gland, Pyloric,Glands, Cardiac,Glands, Gastric,Glands, Pyloric,Mucosa, Gastric,Mucosas, Gastric,Pyloric Gland
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D001471 Barrett Esophagus A condition with damage to the lining of the lower ESOPHAGUS resulting from chronic acid reflux (ESOPHAGITIS, REFLUX). Through the process of metaplasia, the squamous cells are replaced by a columnar epithelium with cells resembling those of the INTESTINE or the salmon-pink mucosa of the STOMACH. Barrett's columnar epithelium is a marker for severe reflux and precursor to ADENOCARCINOMA of the esophagus. Barrett Syndrome,Esophagus, Barrett,Barrett Epithelium,Barrett Metaplasia,Barrett's Esophagus,Barrett's Syndrome,Barrett Metaplasias,Barretts Esophagus,Barretts Syndrome,Epithelium, Barrett,Esophagus, Barrett's,Metaplasia, Barrett,Metaplasias, Barrett
D013194 Staining and Labeling The marking of biological material with a dye or other reagent for the purpose of identifying and quantitating components of tissues, cells or their extracts. Histological Labeling,Staining,Histological Labelings,Labeling and Staining,Labeling, Histological,Labelings, Histological,Stainings
D015260 Neprilysin Enzyme that is a major constituent of kidney brush-border membranes and is also present to a lesser degree in the brain and other tissues. It preferentially catalyzes cleavage at the amino group of hydrophobic residues of the B-chain of insulin as well as opioid peptides and other biologically active peptides. The enzyme is inhibited primarily by EDTA, phosphoramidon, and thiorphan and is reactivated by zinc. Neprilysin is identical to common acute lymphoblastic leukemia antigen (CALLA Antigen), an important marker in the diagnosis of human acute lymphocytic leukemia. There is no relationship with CALLA PLANT. Antigens, CD10,Antigens, Leukemia, Common Acute Lymphoblastic,CALLA Antigen,CD10 Antigens,Common Acute Lymphoblastic Leukemia Antigens,Endopeptidase-24.11,Enkephalin Dipeptidyl Carboxypeptidase,Enkephalinase,Kidney-Brush-Border Neutral Proteinase,Membrane Metallo-Endopeptidase,Atriopeptidase,CD10 Antigen,Enkephalinase-24.11,Neutral Endopeptidase,Neutral Endopeptidase 24.11,Thermolysin-Like Metalloendopeptidase,YGG-Forming Enzyme,Antigen, CD10,Carboxypeptidase, Enkephalin Dipeptidyl,Dipeptidyl Carboxypeptidase, Enkephalin,Endopeptidase 24.11,Endopeptidase 24.11, Neutral,Endopeptidase, Neutral,Enkephalinase 24.11,Enzyme, YGG-Forming,Kidney Brush Border Neutral Proteinase,Membrane Metallo Endopeptidase,Metallo-Endopeptidase, Membrane,Metalloendopeptidase, Thermolysin-Like,Neutral Proteinase, Kidney-Brush-Border,Thermolysin Like Metalloendopeptidase,YGG Forming Enzyme
D055262 Mucin-2 A gel-forming mucin found predominantly in SMALL INTESTINE and variety of mucous membrane-containing organs. It provides a protective, lubricating barrier against particles and infectious agents. Intestinal Mucin-2,Intestinal Mucin 2,Mucin 2,Mucin-2, Intestinal

Related Publications

Soichiro Yamamoto, and Hiroshi Kijima, and Tadashi Hara, and Takahiro Kenmochi, and Yoshifumi Kise, and Hikaru Tanaka, and Osamu Chino, and Hideo Shimada, and Makiko Tanaka, and Sadaki Inokuchi, and Hiroyasu Makuuchi
December 2004, Journal of gastroenterology and hepatology,
Soichiro Yamamoto, and Hiroshi Kijima, and Tadashi Hara, and Takahiro Kenmochi, and Yoshifumi Kise, and Hikaru Tanaka, and Osamu Chino, and Hideo Shimada, and Makiko Tanaka, and Sadaki Inokuchi, and Hiroyasu Makuuchi
June 1998, Journal of clinical gastroenterology,
Soichiro Yamamoto, and Hiroshi Kijima, and Tadashi Hara, and Takahiro Kenmochi, and Yoshifumi Kise, and Hikaru Tanaka, and Osamu Chino, and Hideo Shimada, and Makiko Tanaka, and Sadaki Inokuchi, and Hiroyasu Makuuchi
September 1997, Journal of clinical gastroenterology,
Soichiro Yamamoto, and Hiroshi Kijima, and Tadashi Hara, and Takahiro Kenmochi, and Yoshifumi Kise, and Hikaru Tanaka, and Osamu Chino, and Hideo Shimada, and Makiko Tanaka, and Sadaki Inokuchi, and Hiroyasu Makuuchi
February 2006, Gastroenterology & hepatology,
Soichiro Yamamoto, and Hiroshi Kijima, and Tadashi Hara, and Takahiro Kenmochi, and Yoshifumi Kise, and Hikaru Tanaka, and Osamu Chino, and Hideo Shimada, and Makiko Tanaka, and Sadaki Inokuchi, and Hiroyasu Makuuchi
August 2005, Nihon rinsho. Japanese journal of clinical medicine,
Soichiro Yamamoto, and Hiroshi Kijima, and Tadashi Hara, and Takahiro Kenmochi, and Yoshifumi Kise, and Hikaru Tanaka, and Osamu Chino, and Hideo Shimada, and Makiko Tanaka, and Sadaki Inokuchi, and Hiroyasu Makuuchi
January 2001, Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology,
Soichiro Yamamoto, and Hiroshi Kijima, and Tadashi Hara, and Takahiro Kenmochi, and Yoshifumi Kise, and Hikaru Tanaka, and Osamu Chino, and Hideo Shimada, and Makiko Tanaka, and Sadaki Inokuchi, and Hiroyasu Makuuchi
October 2000, The American journal of managed care,
Soichiro Yamamoto, and Hiroshi Kijima, and Tadashi Hara, and Takahiro Kenmochi, and Yoshifumi Kise, and Hikaru Tanaka, and Osamu Chino, and Hideo Shimada, and Makiko Tanaka, and Sadaki Inokuchi, and Hiroyasu Makuuchi
July 1999, Seminars in gastrointestinal disease,
Soichiro Yamamoto, and Hiroshi Kijima, and Tadashi Hara, and Takahiro Kenmochi, and Yoshifumi Kise, and Hikaru Tanaka, and Osamu Chino, and Hideo Shimada, and Makiko Tanaka, and Sadaki Inokuchi, and Hiroyasu Makuuchi
June 1993, American journal of surgery,
Soichiro Yamamoto, and Hiroshi Kijima, and Tadashi Hara, and Takahiro Kenmochi, and Yoshifumi Kise, and Hikaru Tanaka, and Osamu Chino, and Hideo Shimada, and Makiko Tanaka, and Sadaki Inokuchi, and Hiroyasu Makuuchi
October 1998, Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus,
Copied contents to your clipboard!