Rearrangement of the retino-collicular projection after partial optic nerve crush in the adult rat. 2004

Michael R Kreutz, and Jens Weise, and Daniela C Dieterich, and Martin Kreutz, and Peter Balczarek, and Tobias M Böckers, and Werner Wittkowski, and Eckart D Gundelfinger, and Bernhard A Sabel
AG Molecular Mechanisms of Plasticity, Department of Neurochemistry and Molecular Biology, Leibniz Institute for Neurobiology, Brenneckestrasse 6, 39118 Magdeburg, Germany. Kreutz@ifn-magdeburg.de

The establishment of retino-collicular topography is a well-investigated model of axon pathfinding and it was believed that this topography is irreversibly fixed throughout life. We now report that, after partial crush of the adult rat optic nerve, the anterograde transport of intravitreally-injected tracers via axons of surviving retinal ganglion cells (RGC) in all retinal quadrants is confined to the rostro-medial part of the superior colliculus (SC). This indicates that the retino-collicular topography is rearranged after partial crush of the adult rat optic nerve. The reorganization starts in the injured optic nerve where surviving axonal fibres are demyelinized and bundled in the periphery of the optic nerve distal to the crush site. This is followed by a displacement of surviving axons to the medial part of the optic tract (OT) within 2 weeks. The infiltration of macrophages with the subsequent production of tumour necrosis factor-alpha at the lesion site is a prerequisite for the altered retino-collicular projection as blockade of tumour necrosis factor-alpha signalling with the neutralizing antibody Infliximab abolishes reorganization in the SC and lateralization of RGC axons in the optic nerve and OT. This suggests that optic nerve inflammation is necessary for a progressive bundling of surviving RGC axons, probably via clearance of cellular debris which, in turn, may lead to a redistribution of RGC axons to the medial OT and rostro-medial SC.

UI MeSH Term Description Entries
D009434 Neural Pathways Neural tracts connecting one part of the nervous system with another. Neural Interconnections,Interconnection, Neural,Interconnections, Neural,Neural Interconnection,Neural Pathway,Pathway, Neural,Pathways, Neural
D009473 Neuronal Plasticity The capacity of the NERVOUS SYSTEM to change its reactivity as the result of successive activations. Brain Plasticity,Plasticity, Neuronal,Axon Pruning,Axonal Pruning,Dendrite Arborization,Dendrite Pruning,Dendritic Arborization,Dendritic Pruning,Dendritic Remodeling,Neural Plasticity,Neurite Pruning,Neuronal Arborization,Neuronal Network Remodeling,Neuronal Pruning,Neuronal Remodeling,Neuroplasticity,Synaptic Plasticity,Synaptic Pruning,Arborization, Dendrite,Arborization, Dendritic,Arborization, Neuronal,Arborizations, Dendrite,Arborizations, Dendritic,Arborizations, Neuronal,Axon Prunings,Axonal Prunings,Brain Plasticities,Dendrite Arborizations,Dendrite Prunings,Dendritic Arborizations,Dendritic Prunings,Dendritic Remodelings,Network Remodeling, Neuronal,Network Remodelings, Neuronal,Neural Plasticities,Neurite Prunings,Neuronal Arborizations,Neuronal Network Remodelings,Neuronal Plasticities,Neuronal Prunings,Neuronal Remodelings,Neuroplasticities,Plasticities, Brain,Plasticities, Neural,Plasticities, Neuronal,Plasticities, Synaptic,Plasticity, Brain,Plasticity, Neural,Plasticity, Synaptic,Pruning, Axon,Pruning, Axonal,Pruning, Dendrite,Pruning, Dendritic,Pruning, Neurite,Pruning, Neuronal,Pruning, Synaptic,Prunings, Axon,Prunings, Axonal,Prunings, Dendrite,Prunings, Dendritic,Prunings, Neurite,Prunings, Neuronal,Prunings, Synaptic,Remodeling, Dendritic,Remodeling, Neuronal,Remodeling, Neuronal Network,Remodelings, Dendritic,Remodelings, Neuronal,Remodelings, Neuronal Network,Synaptic Plasticities,Synaptic Prunings
D012160 Retina The ten-layered nervous tissue membrane of the eye. It is continuous with the OPTIC NERVE and receives images of external objects and transmits visual impulses to the brain. Its outer surface is in contact with the CHOROID and the inner surface with the VITREOUS BODY. The outer-most layer is pigmented, whereas the inner nine layers are transparent. Ora Serrata
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D013477 Superior Colliculi The anterior pair of the quadrigeminal bodies which coordinate the general behavioral orienting responses to visual stimuli, such as whole-body turning, and reaching. Colliculus, Superior,Optic Lobe, Human,Optic Lobe, Mammalian,Optic Tectum,Anterior Colliculus,Superior Colliculus,Tectum, Optic,Colliculi, Superior,Colliculus, Anterior,Human Optic Lobe,Human Optic Lobes,Mammalian Optic Lobe,Mammalian Optic Lobes,Optic Lobes, Human,Optic Lobes, Mammalian,Optic Tectums,Tectums, Optic
D017207 Rats, Sprague-Dawley A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company. Holtzman Rat,Rats, Holtzman,Sprague-Dawley Rat,Rats, Sprague Dawley,Holtzman Rats,Rat, Holtzman,Rat, Sprague-Dawley,Sprague Dawley Rat,Sprague Dawley Rats,Sprague-Dawley Rats
D051381 Rats The common name for the genus Rattus. Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus
D020221 Optic Nerve Injuries Injuries to the optic nerve induced by a trauma to the face or head. These may occur with closed or penetrating injuries. Relatively minor compression of the superior aspect of orbit may also result in trauma to the optic nerve. Clinical manifestations may include visual loss, PAPILLEDEMA, and an afferent pupillary defect. Optic Nerve Trauma,Optic Neuropathy, Traumatic,Second Cranial Nerve Trauma,Cranial Nerve II Injuries,Optic Nerve Avulsion,Optic Nerve Contusion,Optic Nerve Transection,Second Cranial Nerve Injuries,Trauma, Second Cranial Nerve,Avulsion, Optic Nerve,Avulsions, Optic Nerve,Contusion, Optic Nerve,Contusions, Optic Nerve,Injuries, Optic Nerve,Injury, Optic Nerve,Nerve Avulsion, Optic,Nerve Avulsions, Optic,Nerve Contusion, Optic,Nerve Contusions, Optic,Nerve Injuries, Optic,Nerve Injury, Optic,Nerve Transection, Optic,Nerve Transections, Optic,Nerve Trauma, Optic,Nerve Traumas, Optic,Neuropathies, Traumatic Optic,Neuropathy, Traumatic Optic,Optic Nerve Avulsions,Optic Nerve Contusions,Optic Nerve Injury,Optic Nerve Transections,Optic Nerve Traumas,Optic Neuropathies, Traumatic,Transection, Optic Nerve,Transections, Optic Nerve,Trauma, Optic Nerve,Traumas, Optic Nerve,Traumatic Optic Neuropathies,Traumatic Optic Neuropathy

Related Publications

Michael R Kreutz, and Jens Weise, and Daniela C Dieterich, and Martin Kreutz, and Peter Balczarek, and Tobias M Böckers, and Werner Wittkowski, and Eckart D Gundelfinger, and Bernhard A Sabel
December 2012, Investigative ophthalmology & visual science,
Michael R Kreutz, and Jens Weise, and Daniela C Dieterich, and Martin Kreutz, and Peter Balczarek, and Tobias M Böckers, and Werner Wittkowski, and Eckart D Gundelfinger, and Bernhard A Sabel
September 2003, Journal of neurotrauma,
Michael R Kreutz, and Jens Weise, and Daniela C Dieterich, and Martin Kreutz, and Peter Balczarek, and Tobias M Böckers, and Werner Wittkowski, and Eckart D Gundelfinger, and Bernhard A Sabel
June 2004, Experimental neurology,
Michael R Kreutz, and Jens Weise, and Daniela C Dieterich, and Martin Kreutz, and Peter Balczarek, and Tobias M Böckers, and Werner Wittkowski, and Eckart D Gundelfinger, and Bernhard A Sabel
June 2013, Investigative ophthalmology & visual science,
Michael R Kreutz, and Jens Weise, and Daniela C Dieterich, and Martin Kreutz, and Peter Balczarek, and Tobias M Böckers, and Werner Wittkowski, and Eckart D Gundelfinger, and Bernhard A Sabel
January 2023, Methods in molecular biology (Clifton, N.J.),
Michael R Kreutz, and Jens Weise, and Daniela C Dieterich, and Martin Kreutz, and Peter Balczarek, and Tobias M Böckers, and Werner Wittkowski, and Eckart D Gundelfinger, and Bernhard A Sabel
June 2002, Experimental eye research,
Michael R Kreutz, and Jens Weise, and Daniela C Dieterich, and Martin Kreutz, and Peter Balczarek, and Tobias M Böckers, and Werner Wittkowski, and Eckart D Gundelfinger, and Bernhard A Sabel
August 2011, Neuroreport,
Michael R Kreutz, and Jens Weise, and Daniela C Dieterich, and Martin Kreutz, and Peter Balczarek, and Tobias M Böckers, and Werner Wittkowski, and Eckart D Gundelfinger, and Bernhard A Sabel
December 2003, European journal of pharmacology,
Michael R Kreutz, and Jens Weise, and Daniela C Dieterich, and Martin Kreutz, and Peter Balczarek, and Tobias M Böckers, and Werner Wittkowski, and Eckart D Gundelfinger, and Bernhard A Sabel
June 1984, Journal of neurocytology,
Michael R Kreutz, and Jens Weise, and Daniela C Dieterich, and Martin Kreutz, and Peter Balczarek, and Tobias M Böckers, and Werner Wittkowski, and Eckart D Gundelfinger, and Bernhard A Sabel
March 2002, Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft,
Copied contents to your clipboard!