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We have examined constitutional chromosome abnormalities and fragile sites in 40 patients with azoospermia. Chromosome abnormalities were found in four cases. Three cases showed a deletion of the long arm of the Y chromosome 46,X,del(Yq) and the other case had a ring of G group chromosome 46,XY,r(G). In a rare fragile sites test, four fragile site carriers were detected and three rare autosomal fragile sites were identified; fra(8)(q24.1), fra(11)(p15.1), and fra(17)(p12). The expression of these fragile sites were induced specifically by AT-specific DNA ligands, such as distamycin A and Hoechst 33258. In addition, one patient was found to be the case of double ascertainment of fragile sites, fra(8)(q24.1) and fra(17)(p12). The overall frequency of distamycin A-inducible fragile sites in azoospermia patients appeared to be higher than those reported for Japanese healthy subjects and cancer patients. However, no significant relation among fragile sites, clinical and histological findings has been detected so far.
N Seki, and
H Sumiya, and
J Shimazaki, and
Y Toyama, and
E Takahashi, and
M Murata, and
T Hori
January 1990,
Cancer genetics and cytogenetics,
N Seki, and
H Sumiya, and
J Shimazaki, and
Y Toyama, and
E Takahashi, and
M Murata, and
T Hori
January 1985,
Cancer genetics and cytogenetics,
N Seki, and
H Sumiya, and
J Shimazaki, and
Y Toyama, and
E Takahashi, and
M Murata, and
T Hori
January 2007,
Annual review of genetics,
N Seki, and
H Sumiya, and
J Shimazaki, and
Y Toyama, and
E Takahashi, and
M Murata, and
T Hori
January 1990,
American journal of medical genetics. Supplement,
N Seki, and
H Sumiya, and
J Shimazaki, and
Y Toyama, and
E Takahashi, and
M Murata, and
T Hori
January 2003,
Cytogenetic and genome research,
N Seki, and
H Sumiya, and
J Shimazaki, and
Y Toyama, and
E Takahashi, and
M Murata, and
T Hori
August 2010,
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics,
N Seki, and
H Sumiya, and
J Shimazaki, and
Y Toyama, and
E Takahashi, and
M Murata, and
T Hori
January 2010,
Journal of assisted reproduction and genetics,
N Seki, and
H Sumiya, and
J Shimazaki, and
Y Toyama, and
E Takahashi, and
M Murata, and
T Hori
January 2005,
Cytogenetic and genome research,
N Seki, and
H Sumiya, and
J Shimazaki, and
Y Toyama, and
E Takahashi, and
M Murata, and
T Hori
June 1990,
American journal of medical genetics,
N Seki, and
H Sumiya, and
J Shimazaki, and
Y Toyama, and
E Takahashi, and
M Murata, and
T Hori
December 1991,
Clinical genetics,
