Activity in the dorsal cochlear nucleus of hamsters previously tested for tinnitus following intense tone exposure. 2004

James A Kaltenbach, and Mark A Zacharek, and Jinsheng Zhang, and Sarah Frederick
Department of Otolaryngology, 5E-UHC, Wayne State University School of Medicine, Detroit, MI 48201, USA. jkalten@med.wayne.edu

Chronic increases in spontaneous multiunit activity can be induced in the dorsal cochlear nucleus (DCN) of hamsters by intense sound exposure (Kaltenbach and McCaslin, 1996). It has been hypothesized that this hyperactivity may represent a neural code that could underlie the sound percepts of tinnitus. The goal of the present study was to determine whether hyperactivity could be demonstrated in animals that had previously been tested for tinnitus, and, if so, whether animals differing in their behavioral evidence for tinnitus also differ in their levels of spontaneous activity. The results showed not only that levels of activity in exposed animals were higher than those in control animals, but the degree to which the activity was increased was related to the strength of the behavioral evidence for tinnitus. These findings are consistent with the hypothesis that hyperactivity in the DCN may be a physiological correlate of noise-induced tinnitus.

UI MeSH Term Description Entries
D007839 Functional Laterality Behavioral manifestations of cerebral dominance in which there is preferential use and superior functioning of either the left or the right side, as in the preferred use of the right hand or right foot. Ambidexterity,Behavioral Laterality,Handedness,Laterality of Motor Control,Mirror Writing,Laterality, Behavioral,Laterality, Functional,Mirror Writings,Motor Control Laterality,Writing, Mirror,Writings, Mirror
D008647 Mesocricetus A genus in the order Rodentia and family Cricetidae. One species, Mesocricetus auratus or golden hamster is widely used in biomedical research. Hamsters, Golden,Hamsters, Golden Syrian,Hamsters, Syrian,Mesocricetus auratus,Syrian Golden Hamster,Syrian Hamster,Golden Hamster,Golden Hamster, Syrian,Golden Hamsters,Golden Syrian Hamsters,Hamster, Golden,Hamster, Syrian,Hamster, Syrian Golden,Syrian Hamsters
D009474 Neurons The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM. Nerve Cells,Cell, Nerve,Cells, Nerve,Nerve Cell,Neuron
D009622 Noise Any sound which is unwanted or interferes with HEARING other sounds. Noise Pollution,Noises,Pollution, Noise
D001931 Brain Mapping Imaging techniques used to colocalize sites of brain functions or physiological activity with brain structures. Brain Electrical Activity Mapping,Functional Cerebral Localization,Topographic Brain Mapping,Brain Mapping, Topographic,Functional Cerebral Localizations,Mapping, Brain,Mapping, Topographic Brain
D006224 Cricetinae A subfamily in the family MURIDAE, comprising the hamsters. Four of the more common genera are Cricetus, CRICETULUS; MESOCRICETUS; and PHODOPUS. Cricetus,Hamsters,Hamster
D000161 Acoustic Stimulation Use of sound to elicit a response in the nervous system. Auditory Stimulation,Stimulation, Acoustic,Stimulation, Auditory
D000200 Action Potentials Abrupt changes in the membrane potential that sweep along the CELL MEMBRANE of excitable cells in response to excitation stimuli. Spike Potentials,Nerve Impulses,Action Potential,Impulse, Nerve,Impulses, Nerve,Nerve Impulse,Potential, Action,Potential, Spike,Potentials, Action,Potentials, Spike,Spike Potential
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D001306 Auditory Pathways NEURAL PATHWAYS and connections within the CENTRAL NERVOUS SYSTEM, beginning at the hair cells of the ORGAN OF CORTI, continuing along the eighth cranial nerve, and terminating at the AUDITORY CORTEX. Auditory Pathway,Pathway, Auditory,Pathways, Auditory

Related Publications

James A Kaltenbach, and Mark A Zacharek, and Jinsheng Zhang, and Sarah Frederick
February 2000, Hearing research,
James A Kaltenbach, and Mark A Zacharek, and Jinsheng Zhang, and Sarah Frederick
August 2002, Hearing research,
James A Kaltenbach, and Mark A Zacharek, and Jinsheng Zhang, and Sarah Frederick
September 2006, Journal of neuroscience research,
James A Kaltenbach, and Mark A Zacharek, and Jinsheng Zhang, and Sarah Frederick
January 2006, Hearing research,
James A Kaltenbach, and Mark A Zacharek, and Jinsheng Zhang, and Sarah Frederick
September 2000, Hearing research,
James A Kaltenbach, and Mark A Zacharek, and Jinsheng Zhang, and Sarah Frederick
October 1998, Hearing research,
James A Kaltenbach, and Mark A Zacharek, and Jinsheng Zhang, and Sarah Frederick
May 1992, Hearing research,
James A Kaltenbach, and Mark A Zacharek, and Jinsheng Zhang, and Sarah Frederick
October 2009, Hearing research,
James A Kaltenbach, and Mark A Zacharek, and Jinsheng Zhang, and Sarah Frederick
January 1996, Auditory neuroscience,
James A Kaltenbach, and Mark A Zacharek, and Jinsheng Zhang, and Sarah Frederick
August 1997, Zhonghua er bi yan hou ke za zhi,
Copied contents to your clipboard!