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Experiments were performed to determine how postprandial motilin, gastrin, and pancreatic polypeptide plasma concentrations measured during vagal blockade relate to coincident small intestinal motility patterns. Feeding produced a postprandial pattern of intestinal motility coincident with a sustained increase in gastrin and pancreatic polypeptide and a decline in motilin plasma concentrations. Vagal blockade replaced the fed pattern with one similar to migrating motor complex (MMC) activity. Highest motilin plasma concentrations were observed during phase III of this MMC-like activity, as occurs in the fasted state. Vagal blockade reduced but did not abolish the postprandial increase in plasma gastrin and pancreatic polypeptide concentrations. Termination of vagal cooling produced a decline in motilin and an elevation in gastrin and pancreatic polypeptide concentrations, coincident with the return of the fed pattern. In conclusion, during vagal blockade in the fed state (i) motilin, but not gastrin or pancreatic polypeptide plasma concentrations, fluctuate with the MMC-like activity, and any measurement of motilin concentration under these circumstances must be interpreted on the basis of gut motility patterns, and (ii) gastrin and pancreatic polypeptide concentrations are marginally elevated, but these changes are not enough to disrupt the MMC or have any motor effect. Lastly, the fed pattern and the postprandial changes in motilin, gastrin, and pancreatic polypeptide concentrations are in part dependent upon intact vagal pathways.
S A Chung, and
G R Greenberg, and
N E Diamant
February 1979,
The Journal of clinical investigation,
S A Chung, and
G R Greenberg, and
N E Diamant
November 1983,
Canadian journal of physiology and pharmacology,
S A Chung, and
G R Greenberg, and
N E Diamant
February 1981,
Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova,
S A Chung, and
G R Greenberg, and
N E Diamant
December 1980,
Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova,
S A Chung, and
G R Greenberg, and
N E Diamant
October 1985,
Digestive diseases and sciences,
S A Chung, and
G R Greenberg, and
N E Diamant
October 1988,
Regulatory peptides,
S A Chung, and
G R Greenberg, and
N E Diamant
January 1984,
Digestion,
S A Chung, and
G R Greenberg, and
N E Diamant
July 1982,
The Journal of pediatrics,
S A Chung, and
G R Greenberg, and
N E Diamant
August 1979,
Clinical biochemistry,
S A Chung, and
G R Greenberg, and
N E Diamant
January 1979,
Surgical forum,
