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The lipid metabolic disorders in chronic renal insufficiency (CRI) are related to increased hepatic lipid synthesis, reduced triglyceride removal coupled with insulin insensitivity and impaired lipoprotein lipase activity. Growth hormone is lipolytic, and the effects of recombinant human growth hormone (rhGH) on the hypercholesterolemia of CRI are unsettled. To test this question, we gave rhGH for 14 days at a dosage of 3 units/day intraperitoneally to two-stage, 5/6 nephrectomized, male Sprague-Dawley rats (n = 18) compared to sex- and age-matched control (n = 27) and CRI (n = 40) rats. At the end of the study, CRI rats and those treated with rhGH had a similar degree of renal impairment, as assessed by serum concentrations (mean +/- SEM) of urea nitrogen (49 +/- 3 vs. 54 +/- 4 mg/dl), creatinine (0.9 +/- 0.0 vs. 1.0 +/- 0.1 mg/dl) and cumulative food intake (311 +/- 8 vs. 290 +/- 12 g). Serum urea nitrogen (16 +/- 4 mg/dl) and creatinine (0.4 +/- 0.1 mg/dl) concentrations as well as food intake (412 +/- 9 g) of control rats were significantly (p < 0.0001) different. Serum cholesterol concentration of CRI rats treated with rhGH (87 +/- 3 mg/dl) was not higher than those of CRI rats (81 +/- 2 mg/dl, p < 0.1338) but was significantly higher than in control rats (55 +/- 3 mg/dl, p < 0.0001). CRI rats treated with rhGH showed a similar serum albumin concentration and lower serum glucose than CRI rats (0.9 +/- 0.1 vs. 0.9 +/- 0.0 g/dl and 144 +/- 4 vs. 163 +/- 3 mg/dl, p < 0.0001).(ABSTRACT TRUNCATED AT 250 WORDS)
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K Niimi, and
J D Hanna, and
J W Foreman, and
A H Perkins
May 1998,
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J C Chan, and
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K Niimi, and
J D Hanna, and
J W Foreman, and
A H Perkins
January 1996,
Kidney international. Supplement,
F Santos, and
J C Chan, and
R J Krieg, and
K Niimi, and
J D Hanna, and
J W Foreman, and
A H Perkins
January 1996,
Kidney international. Supplement,
F Santos, and
J C Chan, and
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K Niimi, and
J D Hanna, and
J W Foreman, and
A H Perkins
January 1993,
Hormone research,
F Santos, and
J C Chan, and
R J Krieg, and
K Niimi, and
J D Hanna, and
J W Foreman, and
A H Perkins
March 1997,
Kidney international. Supplement,
F Santos, and
J C Chan, and
R J Krieg, and
K Niimi, and
J D Hanna, and
J W Foreman, and
A H Perkins
March 1996,
Kidney international,
F Santos, and
J C Chan, and
R J Krieg, and
K Niimi, and
J D Hanna, and
J W Foreman, and
A H Perkins
January 1996,
Archives de pediatrie : organe officiel de la Societe francaise de pediatrie,
F Santos, and
J C Chan, and
R J Krieg, and
K Niimi, and
J D Hanna, and
J W Foreman, and
A H Perkins
January 1996,
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F Santos, and
J C Chan, and
R J Krieg, and
K Niimi, and
J D Hanna, and
J W Foreman, and
A H Perkins
January 1990,
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F Santos, and
J C Chan, and
R J Krieg, and
K Niimi, and
J D Hanna, and
J W Foreman, and
A H Perkins
April 1991,
Journal of the American Society of Nephrology : JASN,
