The adrenal medullary tissue removed from the fetus donor aborted at the age of 24 weeks was cultured for one week. Approximately 200-300 mg tissue was placed at the head of bilateral caudate in 17 severe patients with PD. Follow-up lasted for 3 to 18 months. Improvement was observed in all patients 3 months after grafting. Clinical analysis showed that the efficacy was significant and that one of the 17 patients relapsed. The response rate of 6 to 12 months was 87.5%. Immediately after operation, the drug was withheld or decreased in dosage. The low density areas in the head of caudate nucleus was found by CT within 1 to 10 days, and disappeared one month after operation. We conclude that the human fetal adrenal medullary tissue can survive in the human brain and is associated with functional effect. Transplantation of the brain tissue is useful in the treatment of PD.