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Synthesis of an S-linked glycopeptide analog derived from human Tamm-Horsfall glycoprotein. 2004

Xiangming Zhu, and Tobias Haag, and Richard R Schmidt
Fachbereich Chemie, Universität Konstanz, Fach M 725, D-78457 Konstanz, Germany.

Direct base catalyzed S-glycosylation of a cysteine and a homocysteine containing peptide with O-acetyl protected bromides in DMF-water solution furnished two glycopeptide fragments. The two glycopeptide fragments were linked to the target glycopeptide with two S-glycosyl residues mimicking a part of Tamm-Horsfall glycoprotein.

UI MeSH Term Description Entries
D009088 Mucoproteins Conjugated proteins in which mucopolysaccharides are combined with proteins. The mucopolysaccharide moiety is the predominant group with the protein making up only a small percentage of the total weight.
D003545 Cysteine A thiol-containing non-essential amino acid that is oxidized to form CYSTINE. Cysteine Hydrochloride,Half-Cystine,L-Cysteine,Zinc Cysteinate,Half Cystine,L Cysteine
D006020 Glycopeptides Proteins which contain carbohydrate groups attached covalently to the polypeptide chain. The protein moiety is the predominant group with the carbohydrate making up only a small percentage of the total weight. Glycopeptide
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D058949 Uromodulin A glycosyl-phosphatidyl-inositol (GPI) - anchored membrane protein found on the thick ascending limb of the LOOP OF HENLE. The cleaved form of the protein is found abundantly in URINE. Tamm-Horsfall Glycoprotein,Tamm-Horsfall Protein,Uromucoid,Tamm Horsfall Glycoprotein,Tamm Horsfall Protein

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