The frequency of diabetes and hypertension is increasing worldwide. Diabetes mellitus doubles the risk of cardiovascular diseases, even in hypertensive patients who are already at high risk because of their high blood pressure. Combination of 2 or more drugs is usually needed to achieve the target BP goal of less than 130/85 mmHg. Thiazide diuretic, beta-blockers, ACE inhibitor, ARBs and Ca blockers are beneficial in reducing cardiovascular events. However, the ACE inhibitors- or ARB-based treatments favorably affect the progression of diabetic nephrology and reduce albuminuria.