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A randomized, three-way crossover study by gastroscopic examination in 24 healthy male volunteers was performed to compare the gastric tolerance of a single dose of buffered or unbuffered acetylsalicylic acid. Gastroscopic assessment was made two hours after administration of the buffered (800 mg ASA) or unbuffered (500 mg ASA) tablets taken with 200 ml of water. Mucosal changes were rare and of a minor nature. Only two volunteers in the unbuffered ASA group presented minor changes (erythema and oedema). No pathological changes were observed after the buffered ASA. Subjective adverse reactions, e.g. epigastric complaints, were reported by four volunteers in the unbuffered group and by two in the buffered group. Based on the limited number and the minor extent of visible changes, statistical tests did not appear to be warranted. The results indicate that buffered ASA is better tolerated.
K Rogalla, and
R Lange, and
M Panijel
March 1990,
Zeitschrift fur Gastroenterologie,
K Rogalla, and
R Lange, and
M Panijel
April 1976,
Lakartidningen,
K Rogalla, and
R Lange, and
M Panijel
February 1970,
The American journal of digestive diseases,
K Rogalla, and
R Lange, and
M Panijel
January 1958,
The New England journal of medicine,
K Rogalla, and
R Lange, and
M Panijel
December 1959,
The New England journal of medicine,
K Rogalla, and
R Lange, and
M Panijel
August 1962,
Journal of pharmaceutical sciences,
K Rogalla, and
R Lange, and
M Panijel
January 1983,
Arzneimittel-Forschung,
K Rogalla, and
R Lange, and
M Panijel
July 1994,
Arzneimittel-Forschung,
K Rogalla, and
R Lange, and
M Panijel
March 1990,
Arzneimittel-Forschung,
K Rogalla, and
R Lange, and
M Panijel
June 1992,
Methods and findings in experimental and clinical pharmacology,
