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To assess the reliability of conductance (G) catheter for evaluating right ventricular (RV) volume changes, a miniature (3.5F) six-electrode catheter was developed and tested in 11 New Zealand rabbit hearts. In five animals the heart was excised; in six it was left in the thorax. RV conductance was recorded while the RV was filled with blood in 0.25-ml steps at different left ventricular (LV) volumes. Linear correlation of measured conductance vs. reference volumes was computed. RV conductance was highly correlated with reference volume [correlation coefficient (r) ranging from 0.991 to 0.999]. Slope of regression lines was not significantly affected by LV volume variations in 1-ml steps or by acute conductance changes of structures surrounding the heart, whereas the intercept was affected only by the 0- to 1-ml LV volume change. In four rabbits, RV conductance changes during a cardiac cycle [stroke volume- (SV) G] were compared in vivo with electromagnetic flow probe-derived estimates of SV (SVem) as stroke volume was varied by graded inferior vena caval occlusion. SV-G correlated well with SVem (r ranging from 0.92 to 0.96). This correlation persisted after the thorax was filled with saline; however, significant differences were found in individual slopes (P < 0.001). These results show that the conductance catheter has a potential to reliably monitor in vivo relative RV volume changes in small-animal hearts.
P L Soldà, and
P Pantaleo, and
S Perlini, and
A Calciati, and
G Finardi, and
M R Pinsky, and
L Bernardi
December 1992,
Pacing and clinical electrophysiology : PACE,
P L Soldà, and
P Pantaleo, and
S Perlini, and
A Calciati, and
G Finardi, and
M R Pinsky, and
L Bernardi
January 1996,
Biomedical instrumentation & technology,
P L Soldà, and
P Pantaleo, and
S Perlini, and
A Calciati, and
G Finardi, and
M R Pinsky, and
L Bernardi
October 1995,
European heart journal,
P L Soldà, and
P Pantaleo, and
S Perlini, and
A Calciati, and
G Finardi, and
M R Pinsky, and
L Bernardi
October 2003,
American journal of physiology. Heart and circulatory physiology,
P L Soldà, and
P Pantaleo, and
S Perlini, and
A Calciati, and
G Finardi, and
M R Pinsky, and
L Bernardi
January 1995,
Heart and vessels,
P L Soldà, and
P Pantaleo, and
S Perlini, and
A Calciati, and
G Finardi, and
M R Pinsky, and
L Bernardi
January 2002,
ASAIO journal (American Society for Artificial Internal Organs : 1992),
P L Soldà, and
P Pantaleo, and
S Perlini, and
A Calciati, and
G Finardi, and
M R Pinsky, and
L Bernardi
September 1995,
The American journal of physiology,
P L Soldà, and
P Pantaleo, and
S Perlini, and
A Calciati, and
G Finardi, and
M R Pinsky, and
L Bernardi
February 2014,
Journal of applied physiology (Bethesda, Md. : 1985),
P L Soldà, and
P Pantaleo, and
S Perlini, and
A Calciati, and
G Finardi, and
M R Pinsky, and
L Bernardi
November 1984,
Circulation,
P L Soldà, and
P Pantaleo, and
S Perlini, and
A Calciati, and
G Finardi, and
M R Pinsky, and
L Bernardi
November 1992,
European heart journal,
