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BACKGROUND Postoperative nausea and vomiting (PONV) and pain are the most common complaints following anesthesia and surgery, and due to negative emotional impact on patients, they cause prolonged postoperative recovery. The incidence of PONV is 20-30% during the first 24 h after anesthesia. Both peripheral and central mechanisms are involved in control of emesis. METHODS Many factors associated with anesthesia and surgery may affect PONV: patient's age and sex, history of PONV after pervious anesthesia, administration of antiemetics prior to operation, type and duration of operation, type of premedication, induction agent, maintenance agent, reversal of muscle relaxation, treatment of postoperative pain and movement of patients. ANTAGONISTS OF 5-HYDROXYTRYPTAMINE-3 (5-HT3) RECEPTORS: Ondansetron is a competitive serotonin type 3 receptor antagonist important in prevention of PONV. However, if 5-HT 3 receptor antagonists are effective against nausea and vomiting after a variety of anesthetic and surgical procedures, then at last we may have the key to the mechanism of PONV. Prophylaxis with a combination of antiemetic drugs is more effective in prevention of PONV.
Milanka Tatić, and
Svetlana Skorić, and
Sanja Misković, and
Milena Komarcević, and
Dusanka Dobanovacki, and
Gordana Tomić
January 1960,
Anesthesiology,
Milanka Tatić, and
Svetlana Skorić, and
Sanja Misković, and
Milena Komarcević, and
Dusanka Dobanovacki, and
Gordana Tomić
January 1995,
Minerva anestesiologica,
Milanka Tatić, and
Svetlana Skorić, and
Sanja Misković, and
Milena Komarcević, and
Dusanka Dobanovacki, and
Gordana Tomić
January 1959,
Western journal of surgery, obstetrics, and gynecology,
Milanka Tatić, and
Svetlana Skorić, and
Sanja Misković, and
Milena Komarcević, and
Dusanka Dobanovacki, and
Gordana Tomić
October 2006,
Autonomic neuroscience : basic & clinical,
Milanka Tatić, and
Svetlana Skorić, and
Sanja Misković, and
Milena Komarcević, and
Dusanka Dobanovacki, and
Gordana Tomić
May 1994,
Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke,
Milanka Tatić, and
Svetlana Skorić, and
Sanja Misković, and
Milena Komarcević, and
Dusanka Dobanovacki, and
Gordana Tomić
February 2006,
Ugeskrift for laeger,
Milanka Tatić, and
Svetlana Skorić, and
Sanja Misković, and
Milena Komarcević, and
Dusanka Dobanovacki, and
Gordana Tomić
December 1999,
Current opinion in anaesthesiology,
Milanka Tatić, and
Svetlana Skorić, and
Sanja Misković, and
Milena Komarcević, and
Dusanka Dobanovacki, and
Gordana Tomić
June 2020,
British journal of hospital medicine (London, England : 2005),
Milanka Tatić, and
Svetlana Skorić, and
Sanja Misković, and
Milena Komarcević, and
Dusanka Dobanovacki, and
Gordana Tomić
September 2014,
Korean journal of anesthesiology,
Milanka Tatić, and
Svetlana Skorić, and
Sanja Misković, and
Milena Komarcević, and
Dusanka Dobanovacki, and
Gordana Tomić
October 1992,
The British journal of theatre nursing : NATNews : the official journal of the National Association of Theatre Nurses,
