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Inhibition of the subgenomic hepatitis C virus replicon in huh-7 cells by 2'-deoxy-2'-fluorocytidine. 2004
Lieven J Stuyver, and
Tamara R McBrayer, and
Tony Whitaker, and
Phillip M Tharnish, and
Mangala Ramesh, and
Stefania Lostia, and
Leanne Cartee, and
Junxing Shi, and
Ann Hobbs, and
Raymond F Schinazi, and
Kyoichi A Watanabe, and
Michael J Otto
Pharmasset, Inc., Tucker, Georgia 30084, USA.
2'-Deoxy-2'-fluorocytidine (FdC) is a potent inhibitor of the hepatitis C virus RNA replicon in culture, and FdC-5'-triphosphate is an effective inhibitor of the NS5B polymerase. Dynamic profiling of cell growth in an antiviral assay showed that FdC caused cytostasis due to an S-phase arrest. These observations demonstrate that FdC treatment is affecting both a viral target and a cellular target.
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