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The change of blood volume, of blood and plasma density (rho b, rho p) following a short ultrafiltration pulse (duration: 20 min; mean rate -35 ml/min) within the first hour of hemodialysis was analyzed in 13 hemodynamically stable patients (30 single measurements). Protein concentration of refilling volume (7 g/liter) was calculated from its density (1009.25 +/- 3.7 kg/m3, at 20 degrees C) and from the linear relationship between plasma density and protein concentration (cp) of uremic plasma samples (rho p = 1007.46 + 0.2422 x cp). The filtration coefficient (Lp,calc) determined from a relation derived from Starling's hypothesis was 5.6 +/- 1.4 ml/(min.mm Hg.50 kg lean body mass); N = 13, mean +/- SD, minimum 3.2, maximum 8.0. A model describing the dynamics of blood and plasma volume was developed. It was fit to on-line measurements of relative blood volume changes by variation of the filtration coefficient and of initial blood volume (Lp,fit, Vb,fit). The linear regression between Vb,fit and blood volume determined from anthropometry (Vb,calc) was highly significant (r = 0.79, N = 30, P < 0.001). Compared to Vb,calc, Vb,fit was typically increased by 21 +/- 11%, reflecting a fluid overload at the beginning of the treatment. Lp,fit was not different from Lp,calc. Lp,fit significantly increased with blood volume excess. Due to the small but definite protein content of refilling volume, the model accounts for increased blood volume recovery and occasional overshoot of blood and plasma volumes following ultrafiltration.
D Schneditz, and
J Roob, and
M Oswald, and
H Pogglitsch, and
M Moser, and
T Kenner, and
U Binswanger
February 2016,
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D Schneditz, and
J Roob, and
M Oswald, and
H Pogglitsch, and
M Moser, and
T Kenner, and
U Binswanger
January 1993,
Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis,
D Schneditz, and
J Roob, and
M Oswald, and
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January 1994,
ASAIO journal (American Society for Artificial Internal Organs : 1992),
D Schneditz, and
J Roob, and
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July 2016,
Hemodialysis international. International Symposium on Home Hemodialysis,
D Schneditz, and
J Roob, and
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H Pogglitsch, and
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U Binswanger
January 1994,
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association,
D Schneditz, and
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November 1985,
Kidney international,
D Schneditz, and
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H Pogglitsch, and
M Moser, and
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U Binswanger
May 1980,
Artificial organs,
D Schneditz, and
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U Binswanger
July 1997,
Nihon Hinyokika Gakkai zasshi. The japanese journal of urology,
D Schneditz, and
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January 2019,
American journal of nephrology,
D Schneditz, and
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M Oswald, and
H Pogglitsch, and
M Moser, and
T Kenner, and
U Binswanger
March 2022,
The International journal of artificial organs,
