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The localization of aldose reductase (AR), which is thought to be involved in the pathogenesis of sugar and galactosemic cataracts, has been studied using various methods. The AR exists in the lens and its presence is considered to be important at the site of the cataractogenesis. In this study, the localization of AR messenger RNA (ARmRNA) in the lenses of 3-week old and fetal rats was studied by in situ hybridization using a complementary DNA to the rat AR gene. In the lens of 3-week-old rats, ARmRNA was present in the lens-epithelium and the equatorial superficial cortex. The distribution profile was similar to that of AR-immunoreactivities revealed by an immunocytochemical study. In the fetal lens, however ARmRNA was present in the epithelium and the equatorial region, while AR-immunoreactivity was observed mainly in the center of the lens.
S Okamoto, and
H Terubayashi, and
M Tsutsumi, and
H Ikebe, and
Y Akagi, and
C Nishimura, and
P F Kador
January 1987,
Progress in clinical and biological research,
S Okamoto, and
H Terubayashi, and
M Tsutsumi, and
H Ikebe, and
Y Akagi, and
C Nishimura, and
P F Kador
January 1997,
Advances in experimental medicine and biology,
S Okamoto, and
H Terubayashi, and
M Tsutsumi, and
H Ikebe, and
Y Akagi, and
C Nishimura, and
P F Kador
January 1989,
Progress in clinical and biological research,
S Okamoto, and
H Terubayashi, and
M Tsutsumi, and
H Ikebe, and
Y Akagi, and
C Nishimura, and
P F Kador
December 1989,
Current eye research,
S Okamoto, and
H Terubayashi, and
M Tsutsumi, and
H Ikebe, and
Y Akagi, and
C Nishimura, and
P F Kador
April 1969,
Experimental eye research,
S Okamoto, and
H Terubayashi, and
M Tsutsumi, and
H Ikebe, and
Y Akagi, and
C Nishimura, and
P F Kador
October 1987,
The Biochemical journal,
S Okamoto, and
H Terubayashi, and
M Tsutsumi, and
H Ikebe, and
Y Akagi, and
C Nishimura, and
P F Kador
November 1983,
Experimental eye research,
S Okamoto, and
H Terubayashi, and
M Tsutsumi, and
H Ikebe, and
Y Akagi, and
C Nishimura, and
P F Kador
November 1989,
Investigative ophthalmology & visual science,
S Okamoto, and
H Terubayashi, and
M Tsutsumi, and
H Ikebe, and
Y Akagi, and
C Nishimura, and
P F Kador
October 1986,
Yao xue xue bao = Acta pharmaceutica Sinica,
S Okamoto, and
H Terubayashi, and
M Tsutsumi, and
H Ikebe, and
Y Akagi, and
C Nishimura, and
P F Kador
November 1986,
The Biochemical journal,
