Biomaterial Database

Microbiological control of pharmaceutical products containing preservatives: drawbacks of the method of membrane filtration. 1992

C Casetta, and F Negretti, and C Trabattoni

Chair of Microbiology and Hygiene, Institute of Pharmacological Sciences, Milan.

Microbiological assays carried out on membranes employed for the filtration of solutions of preservatives with concentration used in pharmaceuticals, demonstrated that such membranes, even after washing with 300 ml (100 ml X 3) of peptone water according to the guidelines of the Pharmacopoeia, maintain very frequently a remarkable antimicrobial activity revealed by inhibition zones and by disappearance or decrease of the number of colonies forming units. Such drawbacks can interfere negatively with the microbiological controls of pharmaceuticals containing preservatives.

UI	MeSH Term	Description	Entries
D011310	Preservatives, Pharmaceutical	Substances added to pharmaceutical preparations to protect them from chemical change or microbial action. They include ANTI-BACTERIAL AGENTS and antioxidants.	Pharmaceutic Aids (Preservatives),Pharmaceutic Preservative,Pharmaceutic Preservatives,Pharmaceutical Preservative,Pharmaceutical Preservatives,Preservative, Pharmaceutic,Preservative, Pharmaceutical,Preservatives, Pharmaceutic
D004340	Drug Contamination	The presence of organisms, or any foreign material that makes a drug preparation impure.	Drug Adulteration,Drug Contamination, Chemical,Drug Contamination, Microbial,Drug Contamination, Physical,Drug Impurity,Adulteration, Drug,Chemical Drug Contamination,Chemical Drug Contaminations,Contamination, Chemical Drug,Contamination, Drug,Contamination, Microbial Drug,Contamination, Physical Drug,Contaminations, Chemical Drug,Contaminations, Microbial Drug,Contaminations, Physical Drug,Drug Adulterations,Drug Contaminations,Drug Contaminations, Chemical,Drug Contaminations, Microbial,Drug Contaminations, Physical,Drug Impurities,Impurity, Drug,Microbial Drug Contamination,Microbial Drug Contaminations,Physical Drug Contamination,Physical Drug Contaminations
D014462	Ultrafiltration	The separation of particles from a suspension by passage through a filter with very fine pores. In ultrafiltration the separation is accomplished by convective transport; in DIALYSIS separation relies instead upon differential diffusion. Ultrafiltration occurs naturally and is a laboratory procedure. Artificial ultrafiltration of the blood is referred to as HEMOFILTRATION or HEMODIAFILTRATION (if combined with HEMODIALYSIS).