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A nearly complete recovery of radioactivity was achieved over 14 days following the oral administration of [35S]-S-methyl-L-cysteine sulphoxide and [35S]-S-carboxymethyl-L-cysteine sulphoxide to four healthy male volunteers. The urine was the major pathway of excretion of radioactivity (c. 96% in 0-14 days; c. 59% in 0-24 hours), with the faecal route being relatively unimportant (c. 1.7% in 0-3 days). Inorganic sulphate was an important degradation product, incorporating a substantial proportion of radioactive sulphur derived from these molecules (c. 40% in 0-14 days; c. 20% in 0-24 hours). Subtle differences were noted in the pattern of radioactive sulphate excretion following administration of the two cysteine-sulphoxide compounds, suggesting that their sulphur-containing moieties may enter different catabolic routes.
R H Waring, and
R M Harris, and
G B Steventon, and
S C Mitchell
October 1982,
Biochemical pharmacology,
R H Waring, and
R M Harris, and
G B Steventon, and
S C Mitchell
May 2012,
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R H Waring, and
R M Harris, and
G B Steventon, and
S C Mitchell
January 1982,
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R H Waring, and
R M Harris, and
G B Steventon, and
S C Mitchell
August 1986,
TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik,
R H Waring, and
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G B Steventon, and
S C Mitchell
October 1984,
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R H Waring, and
R M Harris, and
G B Steventon, and
S C Mitchell
June 1960,
Nature,
R H Waring, and
R M Harris, and
G B Steventon, and
S C Mitchell
December 1990,
Archiv der Pharmazie,
R H Waring, and
R M Harris, and
G B Steventon, and
S C Mitchell
January 1988,
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R H Waring, and
R M Harris, and
G B Steventon, and
S C Mitchell
October 1984,
British journal of clinical pharmacology,
R H Waring, and
R M Harris, and
G B Steventon, and
S C Mitchell
October 1987,
The Analyst,
