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Bicarbonate-responsive "soluble" adenylyl cyclase defines a nuclear cAMP microdomain. 2004
Jonathan H Zippin, and
Jeanne Farrell, and
David Huron, and
Margarita Kamenetsky, and
Kenneth C Hess, and
Donald A Fischman, and
Lonny R Levin, and
Jochen Buck
Department of Pharmacology, Joan and Sanford I. Weill Medical College and Graduate School of Medical Sciences of Cornell University, 1300 York Ave., New York, NY 10021, USA.
Bicarbonate-responsive "soluble" adenylyl cyclase resides, in part, inside the mammalian cell nucleus where it stimulates the activity of nuclear protein kinase A to phosphorylate the cAMP response element binding protein (CREB). The existence of this complete and functional, nuclear-localized cAMP pathway establishes that cAMP signals in intracellular microdomains and identifies an alternate pathway leading to CREB activation.
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