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Synthesis, structure and biological activity of 1,2,4-triazolo-1,3-thiazine derivatives. 1992
H Foks, and
W Rudnicka, and
M Głowka, and
R Kaliszan, and
A Nasal, and
B Damasiewicz, and
A Radwańska, and
J Petrusewicz, and
H Trzeciak, and
B Okopień
Department of Organic Chemistry, Medical Academy of Gdańsk, Poland.
A group of condensed triazole-thiazine derivatives (2a-i, 3b, 3j) was obtained in reaction of the corresponding 5-substituted 1,2,4-triazole-3-thiones (1a-j) with epichlorohydrin in alkaline medium. The structure of the compounds synthesized was confirmed by spectral and roentgenographic methods. Tuberculostatic and circulatory activities of the compounds were also studied.
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