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1. Citreoviridin was a potent inhibitor of the soluble mitochondrial ATPase (adenosine triphosphatase) similar to the closely related aurovertins B and D. 2. Citreoviridin inhibited the following mitochondrial energy-linked reactions also: ADP-stimulated respiration in whole mitochondria from ox heart and rat liver; ATP-driven reduction of NAD+ by succinate; ATP-driven NAD transhydrogenase and ATPase from ox heart submitochondrial particles. 3. The dissociation constant (KD) calculated by a simple law-of-mass-action treatment for the citreoviridin--ATPase complex was 0.5--4.2micron for ox-heart mitochondrial preparations and 0.15micron for rat liver mitochondria. 4. Monoacetylation of citreoviridin decreased its inhibitory potency (KD=2--25micron, ox heart; KD=0.7micron, rat liver). Diacetylation greatly decreased the inhibitory potency (KD=60--215micron, ox heart). 5. Hydrogenation of citreoviridin monoacetate diminished its inhibitory potency considerably. 6. No significant enhancement of fluorescence was observed when citreoviridin interacted with the mitochondrial ATPase.
P E Linnett, and
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June 1980,
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P E Linnett, and
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P E Linnett, and
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January 1977,
Biochemical Society transactions,
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March 1970,
The Journal of biological chemistry,
P E Linnett, and
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M D Osselton, and
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January 1977,
The Journal of biological chemistry,
P E Linnett, and
A D Mitchell, and
M D Osselton, and
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October 1983,
Biology of reproduction,
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M D Osselton, and
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December 1981,
Proceedings of the National Academy of Sciences of the United States of America,
