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Sesamol was administered at a dietary level of 2% to groups of 30 male and female F344/DuCrj rats and B6C3F1 mice for 104 and 96 weeks, respectively. Squamous cell carcinomas in the forestomach were induced in nine of 29 (31%) effective male rats, three of 30 (10%) female rats, eleven of 29 (38%) male mice and five of 30 (17%) female mice treated with sesamol. Papillomas developed in ten of 29 (34%) male rats and fourteen of 30 (47%) female rats, but not in any of the mice. Hyperplasias developed in almost all rats and mice of both sexes. Significant differences from control values were found for all three lesions in rats and for carcinoma and hyperplasia categories in mice. The incidences of other tumors in the 2% sesamol group were comparable with control values. In conclusion, sesamol induces squamous cell carcinomas in the forestomach of rats and mice, males being more susceptible than females.
S Tamano, and
M Hirose, and
H Tanaka, and
E Asakawa, and
K Ogawa, and
N Ito
October 1990,
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
S Tamano, and
M Hirose, and
H Tanaka, and
E Asakawa, and
K Ogawa, and
N Ito
July 1993,
Jikken dobutsu. Experimental animals,
S Tamano, and
M Hirose, and
H Tanaka, and
E Asakawa, and
K Ogawa, and
N Ito
September 2003,
Archives of toxicology,
S Tamano, and
M Hirose, and
H Tanaka, and
E Asakawa, and
K Ogawa, and
N Ito
April 1988,
Laboratory animals,
S Tamano, and
M Hirose, and
H Tanaka, and
E Asakawa, and
K Ogawa, and
N Ito
January 1997,
Journal of applied toxicology : JAT,
S Tamano, and
M Hirose, and
H Tanaka, and
E Asakawa, and
K Ogawa, and
N Ito
September 1998,
Toxicology letters,
S Tamano, and
M Hirose, and
H Tanaka, and
E Asakawa, and
K Ogawa, and
N Ito
November 2011,
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
S Tamano, and
M Hirose, and
H Tanaka, and
E Asakawa, and
K Ogawa, and
N Ito
August 1987,
Environmental health perspectives,
S Tamano, and
M Hirose, and
H Tanaka, and
E Asakawa, and
K Ogawa, and
N Ito
December 1990,
Japanese journal of cancer research : Gann,
S Tamano, and
M Hirose, and
H Tanaka, and
E Asakawa, and
K Ogawa, and
N Ito
March 1993,
Carcinogenesis,
