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We studied the effect of TJN-101, a lignan component of Schisandra fruits (Schisandrae fructus), on liver regeneration after partial hepatectomy. TJN-101 was given orally to male Wistar rats 30 min before partial hepatectomy. The mitotic index and the level of DNA synthesis increased after partial hepatectomy and their increase was significantly enhanced by TJN-101. Ornithine decarboxylase (ODC) activity increased in the early stages of liver regeneration and it was also significantly enhanced by TJN-101. Besides, TJN-101 enhanced the increase in hepatic putrescine. These results suggest that TJN-101 stimulates liver regeneration after partial hepatectomy by enhancing ODC activity, which is an important biochemical event in the early stages of liver regeneration.
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M Aburada, and
E Hosoya
February 1990,
Japanese journal of pharmacology,
S Kubo, and
Y Ohkura, and
Y Mizoguchi, and
I Matsui-Yuasa, and
S Otani, and
S Morisawa, and
H Kinoshita, and
S Takeda, and
M Aburada, and
E Hosoya
April 1988,
Nihon yakurigaku zasshi. Folia pharmacologica Japonica,
S Kubo, and
Y Ohkura, and
Y Mizoguchi, and
I Matsui-Yuasa, and
S Otani, and
S Morisawa, and
H Kinoshita, and
S Takeda, and
M Aburada, and
E Hosoya
June 1988,
Chemical & pharmaceutical bulletin,
S Kubo, and
Y Ohkura, and
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I Matsui-Yuasa, and
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S Takeda, and
M Aburada, and
E Hosoya
September 1991,
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan,
S Kubo, and
Y Ohkura, and
Y Mizoguchi, and
I Matsui-Yuasa, and
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S Morisawa, and
H Kinoshita, and
S Takeda, and
M Aburada, and
E Hosoya
September 1991,
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan,
S Kubo, and
Y Ohkura, and
Y Mizoguchi, and
I Matsui-Yuasa, and
S Otani, and
S Morisawa, and
H Kinoshita, and
S Takeda, and
M Aburada, and
E Hosoya
January 1990,
Chemical & pharmaceutical bulletin,
S Kubo, and
Y Ohkura, and
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I Matsui-Yuasa, and
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S Morisawa, and
H Kinoshita, and
S Takeda, and
M Aburada, and
E Hosoya
October 1991,
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan,
S Kubo, and
Y Ohkura, and
Y Mizoguchi, and
I Matsui-Yuasa, and
S Otani, and
S Morisawa, and
H Kinoshita, and
S Takeda, and
M Aburada, and
E Hosoya
July 1987,
Nihon yakurigaku zasshi. Folia pharmacologica Japonica,
S Kubo, and
Y Ohkura, and
Y Mizoguchi, and
I Matsui-Yuasa, and
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H Kinoshita, and
S Takeda, and
M Aburada, and
E Hosoya
February 1989,
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S Kubo, and
Y Ohkura, and
Y Mizoguchi, and
I Matsui-Yuasa, and
S Otani, and
S Morisawa, and
H Kinoshita, and
S Takeda, and
M Aburada, and
E Hosoya
June 1987,
Japanese journal of pharmacology,
