Clinical effects of cortisone administered orally to patients with rheumatoid arthritis.
1951
L E WARD, and
C H SLOCUMB, and
H F POLLEY, and
E W LOWMAN, and
P S HENCH
UI
MeSH Term
Description
Entries
D003348
Cortisone
A naturally occurring glucocorticoid that has been used in replacement therapy for ADRENAL INSUFFICIENCY and as an anti-inflammatory agent. Cortisone itself is inactive; it is converted in the liver to the active metabolite HYDROCORTISONE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p726)
A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.
Rheumatoid Arthritis
Related Publications
L E WARD, and
C H SLOCUMB, and
H F POLLEY, and
E W LOWMAN, and
P S HENCH