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Changes in the total cobalamin content and spectrum of individual forms of these vitamins in blood cells and plasma as well as the activities of enzymatic systems of xenobiotic metabolism in liver microsomes of rats with experimental adjuvant arthritis (AA) have been studied. The total cobalamin content in the blood plasma of rats with AA was increased in comparison with intact animals; however, leucocytes from AA rats were deficient in methylcobalamin (MeCbl). A correlation was found between the ratios of individual cobalamin forms and their total content which was differently expressed in experimental and control animals. The development of AA was associated with marked inhibition of the cytochrome P-450-dependent monooxygenase system of the liver and glutathione transferase. The possibility of correction of these disturbances by MeCbl is discussed.
V V Bartkiavichene, and
A I Alenene, and
S I Kanopkaĭte, and
V I Astrauskas, and
L K Leonavichene, and
T L Korsova, and
N A Morozova, and
E S Tsukerman, and
A E Liubarev, and
A A Poznanskaia
July 1986,
Toxicology and applied pharmacology,
V V Bartkiavichene, and
A I Alenene, and
S I Kanopkaĭte, and
V I Astrauskas, and
L K Leonavichene, and
T L Korsova, and
N A Morozova, and
E S Tsukerman, and
A E Liubarev, and
A A Poznanskaia
May 1993,
Biochimica et biophysica acta,
V V Bartkiavichene, and
A I Alenene, and
S I Kanopkaĭte, and
V I Astrauskas, and
L K Leonavichene, and
T L Korsova, and
N A Morozova, and
E S Tsukerman, and
A E Liubarev, and
A A Poznanskaia
April 1988,
Biochemical pharmacology,
V V Bartkiavichene, and
A I Alenene, and
S I Kanopkaĭte, and
V I Astrauskas, and
L K Leonavichene, and
T L Korsova, and
N A Morozova, and
E S Tsukerman, and
A E Liubarev, and
A A Poznanskaia
June 2016,
Toxicology in vitro : an international journal published in association with BIBRA,
V V Bartkiavichene, and
A I Alenene, and
S I Kanopkaĭte, and
V I Astrauskas, and
L K Leonavichene, and
T L Korsova, and
N A Morozova, and
E S Tsukerman, and
A E Liubarev, and
A A Poznanskaia
February 1985,
Fundamental and applied toxicology : official journal of the Society of Toxicology,
V V Bartkiavichene, and
A I Alenene, and
S I Kanopkaĭte, and
V I Astrauskas, and
L K Leonavichene, and
T L Korsova, and
N A Morozova, and
E S Tsukerman, and
A E Liubarev, and
A A Poznanskaia
October 1987,
Molecular pharmacology,
V V Bartkiavichene, and
A I Alenene, and
S I Kanopkaĭte, and
V I Astrauskas, and
L K Leonavichene, and
T L Korsova, and
N A Morozova, and
E S Tsukerman, and
A E Liubarev, and
A A Poznanskaia
December 1976,
Biochemical pharmacology,
V V Bartkiavichene, and
A I Alenene, and
S I Kanopkaĭte, and
V I Astrauskas, and
L K Leonavichene, and
T L Korsova, and
N A Morozova, and
E S Tsukerman, and
A E Liubarev, and
A A Poznanskaia
January 1993,
International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition,
V V Bartkiavichene, and
A I Alenene, and
S I Kanopkaĭte, and
V I Astrauskas, and
L K Leonavichene, and
T L Korsova, and
N A Morozova, and
E S Tsukerman, and
A E Liubarev, and
A A Poznanskaia
June 1991,
Research communications in chemical pathology and pharmacology,
V V Bartkiavichene, and
A I Alenene, and
S I Kanopkaĭte, and
V I Astrauskas, and
L K Leonavichene, and
T L Korsova, and
N A Morozova, and
E S Tsukerman, and
A E Liubarev, and
A A Poznanskaia
October 1993,
Biochemical pharmacology,
