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Different pathomechanisms in the development of pulmonary edema are being discussed. We investigated the effect of pathogenetically varying forms of edema on lung vascular barrier function in isolated cell-free perfused rabbit lungs. As an index of permeability, capillary filtration coefficients (Kfc) were determined from the slope of lung weight change over periods of stepwise venous pressure elevation (5, 7.5, and 10 mmHg) before (controls) and 60 min after edema induction. Edema was induced by venous congestion (n = 6), by application of arachidonic acid in the presence of diclofenac sodium (n = 6), and by elastase application (n = 6). Control values ranged from 0.28 to 0.51 ml.min-1 x mmHg-1 x 100 g-1. Kfc was significantly enhanced after edema induction up to 243% of control value in the hydrostatic edema, 357% in the arachidonic acid edema, and 594% in the elastase edema. When the alterations in capillary filtration due to the different types of edema were compared, Kfc was significantly higher in the proteinase edema, indicating an irreversibly damaged barrier function. These data exemplify different pathophysiological characteristics due to the pathogenesis of interstitial edema formation.
T Koch, and
H P Duncker, and
S Rosenkranz, and
H Neuhof, and
K Van Ackern
December 2007,
Respiratory physiology & neurobiology,
T Koch, and
H P Duncker, and
S Rosenkranz, and
H Neuhof, and
K Van Ackern
January 1982,
Patologicheskaia fiziologiia i eksperimental'naia terapiia,
T Koch, and
H P Duncker, and
S Rosenkranz, and
H Neuhof, and
K Van Ackern
October 1978,
The American review of respiratory disease,
T Koch, and
H P Duncker, and
S Rosenkranz, and
H Neuhof, and
K Van Ackern
January 1980,
Progress in cardiovascular diseases,
T Koch, and
H P Duncker, and
S Rosenkranz, and
H Neuhof, and
K Van Ackern
April 1955,
Medical times,
T Koch, and
H P Duncker, and
S Rosenkranz, and
H Neuhof, and
K Van Ackern
November 1949,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
T Koch, and
H P Duncker, and
S Rosenkranz, and
H Neuhof, and
K Van Ackern
September 1937,
The Journal of experimental medicine,
T Koch, and
H P Duncker, and
S Rosenkranz, and
H Neuhof, and
K Van Ackern
July 1977,
Microvascular research,
T Koch, and
H P Duncker, and
S Rosenkranz, and
H Neuhof, and
K Van Ackern
July 1977,
Microvascular research,
T Koch, and
H P Duncker, and
S Rosenkranz, and
H Neuhof, and
K Van Ackern
April 1992,
Harefuah,
