-transparent.png){kind=logo}
Cells from cutaneous neurofibromas of three patients with von Recklinghausen's disease and skin fibroblasts from four healthy adults were cultured. After two passages, DNA and collagen syntheses were determined by measuring incorporation of [3H] thymidine and [3H] proline respectively, and expressed as the values per unit DNA content. These values from neurofibroma cells were increased by 54% in DNA synthesis and 60% (p < 0.05) in nondialyzable hydroxyproline synthesis, suggesting that neurofibroma cells in culture even after several passages still possess those characteristics corresponding to their pathological features in vivo. Collagen synthesized by neurofibroma cells appears to be normal as judged by intracellular degradation rates and SDS-polyacrylamide gel electrophoresis.
T Sasaki, and
K Arai, and
Y Nagai
March 1971,
Israel journal of medical sciences,
T Sasaki, and
K Arai, and
Y Nagai
August 1993,
Biomaterials,
T Sasaki, and
K Arai, and
Y Nagai
January 1977,
Surgical forum,
T Sasaki, and
K Arai, and
Y Nagai
March 1971,
Experimental cell research,
T Sasaki, and
K Arai, and
Y Nagai
September 1975,
Annals of the New York Academy of Sciences,
T Sasaki, and
K Arai, and
Y Nagai
May 1967,
Journal of molecular biology,
T Sasaki, and
K Arai, and
Y Nagai
May 1992,
Biochemical Society transactions,
T Sasaki, and
K Arai, and
Y Nagai
April 1989,
European journal of cell biology,
T Sasaki, and
K Arai, and
Y Nagai
July 1979,
Biochimica et biophysica acta,
T Sasaki, and
K Arai, and
Y Nagai
May 1974,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
