-transparent.png){kind=logo}
Nitrogen mustard as induction therapy for rheumatoid arthritis: clinical and immunologic effects. 1992
T Danao, and
T Ropos, and
W Wilke, and
A Segal, and
L Calabrese, and
R Valenzuela, and
L Gragg, and
J Clough
Department of Rheumatic and Immunologic Disease, Cleveland Clinic Foundation, Ohio 44195.
We treated 5 patients diagnosed with rheumatoid arthritis (RA) with nitrogen mustard (HN2) and monitored clinical and immunologic variables. HN2, 0.3 mg/kg ideal body weight was given over 7 days. Disease activity and immune function were monitored during and after treatment. Duration of morning stiffness (p = 0.0044), joint count (p = 0.0140), and assessment of pain (p = 0.0264) and function (p = 0.0057) improved by Day 6. T lymphocytes (p = 0.0060), especially T memory cells (CD4CD29; p = 0.0017) fell dramatically. HN2 is effective for rapidly gaining control of active RA. This effect is T cell specific.
Related Publications
T Danao, and
T Ropos, and
W Wilke, and
A Segal, and
L Calabrese, and
R Valenzuela, and
L Gragg, and
J Clough
January 1953,
Il Friuli medico,
T Danao, and
T Ropos, and
W Wilke, and
A Segal, and
L Calabrese, and
R Valenzuela, and
L Gragg, and
J Clough
June 1954,
Archives of physical medicine and rehabilitation,
T Danao, and
T Ropos, and
W Wilke, and
A Segal, and
L Calabrese, and
R Valenzuela, and
L Gragg, and
J Clough
January 1953,
Revista clinica espanola,
T Danao, and
T Ropos, and
W Wilke, and
A Segal, and
L Calabrese, and
R Valenzuela, and
L Gragg, and
J Clough
March 1952,
Il Policlinico. Sezione pratica,
T Danao, and
T Ropos, and
W Wilke, and
A Segal, and
L Calabrese, and
R Valenzuela, and
L Gragg, and
J Clough
January 1972,
Reumatismo,
T Danao, and
T Ropos, and
W Wilke, and
A Segal, and
L Calabrese, and
R Valenzuela, and
L Gragg, and
J Clough
March 1983,
Clinical rheumatology,
T Danao, and
T Ropos, and
W Wilke, and
A Segal, and
L Calabrese, and
R Valenzuela, and
L Gragg, and
J Clough
September 1951,
Revista clinica espanola,
T Danao, and
T Ropos, and
W Wilke, and
A Segal, and
L Calabrese, and
R Valenzuela, and
L Gragg, and
J Clough
May 1953,
Journal of the American Medical Association,
T Danao, and
T Ropos, and
W Wilke, and
A Segal, and
L Calabrese, and
R Valenzuela, and
L Gragg, and
J Clough
December 1984,
Clinical rheumatology,
T Danao, and
T Ropos, and
W Wilke, and
A Segal, and
L Calabrese, and
R Valenzuela, and
L Gragg, and
J Clough
January 1960,
Acta rheumatologica Scandinavica,
