Biomaterial Database

[Licorice extract and glycyrrhizinic acid in therapy of Addison's disease]. 1951

J GROEN, and H E PELSER, and M FRENKEL, and A F WILLEBRANDS, and C E KAMMINGA

UI	MeSH Term	Description	Entries
D006035	Glycyrrhiza	A genus of leguminous herbs or shrubs whose roots yield GLYCYRRHETINIC ACID and its derivative, CARBENOXOLONE.	Licorice,Glycyrrhiza glabra,Liquorice,Licorices,Liquorices
D000075262	Hypoadrenocorticism, Familial	Hereditary forms of Addison disease that may exhibit autosomal recessive or X-linked inheritance. They are characterized by severe neurological symptoms, APNEA; and death in infancy. OMIM: 240200	AHC with Isolated Gonadotropin Deficiency,Addison Disease, X-Linked,Adrenal Hypoplasia, Congenital,Adrenal Hypoplasia, Congenital, with Hypogonadotropic Hypogonadism,Complex Glycerol Kinase Deficiency,Cytomegalic Adrenocortical Hypoplasia,Familial X-linked Addison Disease,X-linked Adrenal Hypoplasia,X-linked Congenital Adrenal Hypoplasia,Xp21 Contiguous Gene Deletion Syndrome,Addison Disease, X Linked,Adrenal Hypoplasia, X-linked,Congenital Adrenal Hypoplasia,Congenital Adrenal Hypoplasias,Cytomegalic Adrenocortical Hypoplasias,Familial Hypoadrenocorticism,Familial Hypoadrenocorticisms,Familial X linked Addison Disease,Hypoadrenocorticisms, Familial,Hypoplasia, Congenital Adrenal,X linked Adrenal Hypoplasia,X linked Congenital Adrenal Hypoplasia,X-Linked Addison Disease
D000224	Addison Disease	An adrenal disease characterized by the progressive destruction of the ADRENAL CORTEX, resulting in insufficient production of ALDOSTERONE and HYDROCORTISONE. Clinical symptoms include ANOREXIA; NAUSEA; WEIGHT LOSS; MUSCLE WEAKNESS; and HYPERPIGMENTATION of the SKIN due to increase in circulating levels of ACTH precursor hormone which stimulates MELANOCYTES.	Addison's Disease,Primary Adrenal Insufficiency,Primary Adrenocortical Insufficiency,Primary Hypoadrenalism,Addisons Disease,Adrenal Insufficiency, Primary,Adrenocortical Insufficiencies, Primary,Adrenocortical Insufficiency, Primary,Disease, Addison,Hypoadrenalism, Primary,Hypoadrenalisms, Primary,Insufficiencies, Primary Adrenocortical,Insufficiency, Primary Adrenocortical,Primary Adrenocortical Insufficiencies
D000309	Adrenal Insufficiency	Conditions in which the production of adrenal CORTICOSTEROIDS falls below the requirement of the body. Adrenal insufficiency can be caused by defects in the ADRENAL GLANDS, the PITUITARY GLAND, or the HYPOTHALAMUS.	Adrenal Gland Hypofunction,Hypoadrenalism,Adrenal Insufficiencies,Hypofunction, Adrenal Gland
D019695	Glycyrrhizic Acid	A widely used anti-inflammatory agent isolated from the licorice root. It is metabolized to GLYCYRRHETINIC ACID, which inhibits 11-BETA-HYDROXYSTEROID DEHYDROGENASES and other enzymes involved in the metabolism of CORTICOSTEROIDS. Therefore, glycyrrhizic acid, which is the main and sweet component of licorice, has been investigated for its ability to cause hypermineralocorticoidism with sodium retention and potassium loss, edema, increased blood pressure, as well as depression of the renin-angiotensin-aldosterone system.	Glycyrrhizin,Diammonium Glycyrrhizinate,Dipotassium Glycyrrhizinate,Glycyrrhizinic Acid,Zinc Glycyrrhizate,Acid, Glycyrrhizic,Acid, Glycyrrhizinic,Glycyrrhizate, Zinc,Glycyrrhizinate, Diammonium,Glycyrrhizinate, Dipotassium