-transparent.png){kind=logo}
This study prospectively evaluated the potential interaction between the oral anticoagulant warfarin and the quinolone antimicrobial agent ciprofloxacin. After a 10-day placebo lead-in phase, 16 patients stabilized with long-term warfarin therapy were randomized to receive ciprofloxacin 500 mg or a matching placebo twice/day for 10 days. International normalized ratios (INRs) measured by both standard laboratory analysis and by Coumatrak (finger-stick) methods were evaluated at 3- to 5-day intervals. No patient experienced a significant increase in INR. No patient experienced a bleeding event. These data support the fact that a warfarin-ciprofloxacin interaction does not routinely occur at this dosage and duration of ciprofloxacin therapy.
T M Bianco, and
H I Bussey, and
L E Farnett, and
W D Linn, and
M K Roush, and
Y W Wong
November 1998,
British journal of haematology,
T M Bianco, and
H I Bussey, and
L E Farnett, and
W D Linn, and
M K Roush, and
Y W Wong
July 1995,
Archives of internal medicine,
T M Bianco, and
H I Bussey, and
L E Farnett, and
W D Linn, and
M K Roush, and
Y W Wong
October 2018,
Circulation,
T M Bianco, and
H I Bussey, and
L E Farnett, and
W D Linn, and
M K Roush, and
Y W Wong
February 2014,
Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus,
T M Bianco, and
H I Bussey, and
L E Farnett, and
W D Linn, and
M K Roush, and
Y W Wong
July 2016,
Journal of the American Heart Association,
T M Bianco, and
H I Bussey, and
L E Farnett, and
W D Linn, and
M K Roush, and
Y W Wong
December 1991,
DICP : the annals of pharmacotherapy,
T M Bianco, and
H I Bussey, and
L E Farnett, and
W D Linn, and
M K Roush, and
Y W Wong
October 2022,
Thrombosis journal,
T M Bianco, and
H I Bussey, and
L E Farnett, and
W D Linn, and
M K Roush, and
Y W Wong
August 1989,
American journal of ophthalmology,
T M Bianco, and
H I Bussey, and
L E Farnett, and
W D Linn, and
M K Roush, and
Y W Wong
March 1989,
Clinical pharmacy,
T M Bianco, and
H I Bussey, and
L E Farnett, and
W D Linn, and
M K Roush, and
Y W Wong
June 1991,
The American journal of medicine,
