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The inactivation or loss of tumor suppressor genes (anti-oncogenes) has been implicated as a mechanism central to the pathogenesis of many solid tumors. More recently, we and others have identified a role of one rumor suppressor gene, the retinoblastoma gene, in the development of human lymphoid lymphoma and leukemia. Here we review the involvement of the retinoblastoma gene in the control of normal lymphocyte cell division and the consequences of inactivation of the retinoblastoma gene for the development of lymphoid neoplasia. Our survey has disclosed a broad involvement of retinoblastoma gene inactivation in a wide variety of non-Hodgkin's lymphomas and lymphocytic leukemia. Based on these early findings, it appears likely that tumor suppressor genes may well be involved in many hematopoietic neoplasma.
A M Ginsberg, and
M Raffeld, and
J Cossman
March 1994,
The New England journal of medicine,
A M Ginsberg, and
M Raffeld, and
J Cossman
April 1994,
International journal of oncology,
A M Ginsberg, and
M Raffeld, and
J Cossman
December 1995,
The Prostate,
A M Ginsberg, and
M Raffeld, and
J Cossman
April 1995,
British journal of cancer,
A M Ginsberg, and
M Raffeld, and
J Cossman
October 1996,
Investigative ophthalmology & visual science,
A M Ginsberg, and
M Raffeld, and
J Cossman
January 1999,
Human mutation,
A M Ginsberg, and
M Raffeld, and
J Cossman
January 1996,
Methods in molecular medicine,
A M Ginsberg, and
M Raffeld, and
J Cossman
August 2006,
Oncogene,
A M Ginsberg, and
M Raffeld, and
J Cossman
February 1994,
The Journal of clinical endocrinology and metabolism,
A M Ginsberg, and
M Raffeld, and
J Cossman
November 1998,
Blood,
