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Pancreatic tissue from neonatal rats was cultured for 6 days and then transplanted into isologous animals made diabetic with streptozotocin. The cultured pancreatic tissue was implanted either into the peritoneal cavity or into muscle pockets and showed survival by functional and morphological studies for longer than 40 weeks. Pancreatic tissue from a patient subjected to subtotal pancreatectomy for chronic pancreatitis was maintained in culture for 7 days, with evidence for insulin release into medium, sterility, and histological viability of islets. Autotransplantation of this tissue into muscle pockets of the forearm was tolerated well. Glucose tolerance improved following transplantation, but evidence for function of the graft (insulin, C-peptide) remains inconclusive, 4 months after transplantation.
C J Weber, and
M A Hardy, and
F Pi-Sunyer, and
E Zimmerman, and
K Reemtsma
January 1976,
Acta endocrinologica. Supplementum,
C J Weber, and
M A Hardy, and
F Pi-Sunyer, and
E Zimmerman, and
K Reemtsma
March 1977,
Transplantation proceedings,
C J Weber, and
M A Hardy, and
F Pi-Sunyer, and
E Zimmerman, and
K Reemtsma
February 1978,
Surgery,
C J Weber, and
M A Hardy, and
F Pi-Sunyer, and
E Zimmerman, and
K Reemtsma
June 1979,
Transplantation proceedings,
C J Weber, and
M A Hardy, and
F Pi-Sunyer, and
E Zimmerman, and
K Reemtsma
January 2022,
Cell transplantation,
C J Weber, and
M A Hardy, and
F Pi-Sunyer, and
E Zimmerman, and
K Reemtsma
July 1999,
Pancreas,
C J Weber, and
M A Hardy, and
F Pi-Sunyer, and
E Zimmerman, and
K Reemtsma
January 2012,
Islets,
C J Weber, and
M A Hardy, and
F Pi-Sunyer, and
E Zimmerman, and
K Reemtsma
February 1994,
Transplantation,
C J Weber, and
M A Hardy, and
F Pi-Sunyer, and
E Zimmerman, and
K Reemtsma
January 1972,
Diabetes,
C J Weber, and
M A Hardy, and
F Pi-Sunyer, and
E Zimmerman, and
K Reemtsma
January 1979,
Advances in experimental medicine and biology,
