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Treatment of hypertension; results with hexamethonium salts administered orally. 1952

I JOHNSON, and J H MOYER, and L C MILLS, and S I MILLER

UI MeSH Term Description Entries
D006973 Hypertension Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more. Blood Pressure, High,Blood Pressures, High,High Blood Pressure,High Blood Pressures
D009125 Muscle Relaxants, Central A heterogeneous group of drugs used to produce muscle relaxation, excepting the neuromuscular blocking agents. They have their primary clinical and therapeutic uses in the treatment of muscle spasm and immobility associated with strains, sprains, and injuries of the back and, to a lesser degree, injuries to the neck. They have been used also for the treatment of a variety of clinical conditions that have in common only the presence of skeletal muscle hyperactivity, for example, the muscle spasms that can occur in MULTIPLE SCLEROSIS. (From Smith and Reynard, Textbook of Pharmacology, 1991, p358) Centrally Acting Muscle Relaxants,Central Muscle Relaxants,Relaxants, Central Muscle
D002317 Cardiovascular Agents Agents that affect the rate or intensity of cardiac contraction, blood vessel diameter, or blood volume. Cardioactive Agent,Cardioactive Drug,Cardiovascular Agent,Cardiovascular Drug,Cardioactive Agents,Cardioactive Drugs,Cardiovascular Drugs,Agent, Cardioactive,Agent, Cardiovascular,Drug, Cardioactive,Drug, Cardiovascular
D012492 Salts Substances produced from the reaction between acids and bases; compounds consisting of a metal (positive) and nonmetal (negative) radical. (Grant & Hackh's Chemical Dictionary, 5th ed) Salt
D018738 Hexamethonium A nicotinic cholinergic antagonist often referred to as the prototypical ganglionic blocker. It is poorly absorbed from the gastrointestinal tract and does not cross the blood-brain barrier. It has been used for a variety of therapeutic purposes including hypertension but, like the other ganglionic blockers, it has been replaced by more specific drugs for most purposes, although it is widely used a research tool. Depressin,Hexamethonium Bitartrate,Hexamethonium Bromide,Hexamethonium Chloride,Hexamethonium Dibromide,Hexamethonium Dibromide Dihydrate,Hexamethonium Dichloride Dihydrate,Hexamethonium Dihydroxide,Hexamethonium Diiodide,Hexamethonium Dimethylsulfate,Hexamethonium Diperchlorate,Hexamethonium Iodide,Hexamethonium Monotartrate,Hexonium,Bitartrate, Hexamethonium,Bromide, Hexamethonium,Chloride, Hexamethonium,Dibromide Dihydrate, Hexamethonium,Dibromide, Hexamethonium,Dichloride Dihydrate, Hexamethonium,Dihydrate, Hexamethonium Dibromide,Dihydrate, Hexamethonium Dichloride,Dihydroxide, Hexamethonium,Diiodide, Hexamethonium,Dimethylsulfate, Hexamethonium,Diperchlorate, Hexamethonium,Iodide, Hexamethonium,Monotartrate, Hexamethonium

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