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The influence of the two anthracyclin antibiotics daunomycin and adriamycin on the proteome of Bacillus subtilis was investigated. They intercalate in the double helix causing strand breaks. Both compounds induce proteins related to DNA damage and oxidative stress as indicated by the induction of some members of the PerR and the DinR-regulon. The mild induction of some members of the HrcA- and the CtsR-regulon may indicate protein oxidation as well. Furthermore, an influence on the sigmaB-dependent general stress response was shown. These data show that the proteomic signature is a valuable experimental tool for a comprehensive evaluation of the action of different drugs.
U Sender, and
J Bandow, and
S Engelmann, and
U Lindequist, and
M Hecker
February 2008,
Expert review of proteomics,
U Sender, and
J Bandow, and
S Engelmann, and
U Lindequist, and
M Hecker
October 1974,
Cancer research,
U Sender, and
J Bandow, and
S Engelmann, and
U Lindequist, and
M Hecker
January 1975,
Giornale italiano di chemioterapia,
U Sender, and
J Bandow, and
S Engelmann, and
U Lindequist, and
M Hecker
January 2006,
Methods of biochemical analysis,
U Sender, and
J Bandow, and
S Engelmann, and
U Lindequist, and
M Hecker
October 1979,
The Journal of antibiotics,
U Sender, and
J Bandow, and
S Engelmann, and
U Lindequist, and
M Hecker
January 1977,
Neoplasma,
U Sender, and
J Bandow, and
S Engelmann, and
U Lindequist, and
M Hecker
August 1976,
Annals of internal medicine,
U Sender, and
J Bandow, and
S Engelmann, and
U Lindequist, and
M Hecker
February 2003,
Journal of bacteriology,
U Sender, and
J Bandow, and
S Engelmann, and
U Lindequist, and
M Hecker
June 1973,
Biochemical medicine,
U Sender, and
J Bandow, and
S Engelmann, and
U Lindequist, and
M Hecker
February 1976,
Cancer,
