-transparent.png){kind=logo}
By the enzyme-labeled antibody method, cells containing somatostatin (SRIF) as well as insulin or glucagon were identified in pancreatic islets of the rat. SRIF antiserum was raised in rabbits followin immunization with synthetic SRIF coupled with human serum alpha-globulin and did not cross-react with hypothalamic, pituitary or gastrointestinal hormones using our immunoassay method. In the control rats, SRIF-containing cells were scattered in the periphery of the islets in close proximity to the outer glucagon containing cells. These latter cells were distributed in the outermost periphery of the islets. Insulin-containing cells were located in the central portion of the islets and dominantly occupied most of the islet. In the streptozotocin-diabetic rat, SRIF-containing cells were significantly increased in number whereas insulin-containing cells were markedly reduced. It is suggested from these findings that the number as well as the distribution of SRIF-, insulin- and glucagon-containing cells was important to the physiological and pathophysiological functioning of the islet.
Y Matsushima, and
H Makino, and
A Kanatsuka, and
M Yamamoto, and
A Kumagai
January 1985,
Virchows Archiv. A, Pathological anatomy and histopathology,
Y Matsushima, and
H Makino, and
A Kanatsuka, and
M Yamamoto, and
A Kumagai
December 1980,
Molecular and cellular endocrinology,
Y Matsushima, and
H Makino, and
A Kanatsuka, and
M Yamamoto, and
A Kumagai
December 1985,
Sichuan yi xue yuan xue bao = Acta Academiae Medicinae Sichuan,
Y Matsushima, and
H Makino, and
A Kanatsuka, and
M Yamamoto, and
A Kumagai
March 1976,
Clinical endocrinology,
Y Matsushima, and
H Makino, and
A Kanatsuka, and
M Yamamoto, and
A Kumagai
October 1998,
The Journal of clinical endocrinology and metabolism,
Y Matsushima, and
H Makino, and
A Kanatsuka, and
M Yamamoto, and
A Kumagai
September 2007,
Methods and findings in experimental and clinical pharmacology,
Y Matsushima, and
H Makino, and
A Kanatsuka, and
M Yamamoto, and
A Kumagai
January 1978,
Acta biologica et medica Germanica,
Y Matsushima, and
H Makino, and
A Kanatsuka, and
M Yamamoto, and
A Kumagai
April 1993,
Biochemical medicine and metabolic biology,
Y Matsushima, and
H Makino, and
A Kanatsuka, and
M Yamamoto, and
A Kumagai
January 2015,
Morfologiia (Saint Petersburg, Russia),
Y Matsushima, and
H Makino, and
A Kanatsuka, and
M Yamamoto, and
A Kumagai
January 1978,
The Tohoku journal of experimental medicine,
