BIOMAT Database Logo BIOMAT Database Logo

Toxicologic evaluation of the new cyclosporin derivative, SDZ IMM 125, in a comparative, subchronic toxicity study in rats. 1992

P Donatsch, and J Mason, and B P Richardson, and B Ryffel
Preclinical Research, Sandoz Pharma, Ltd, Basel, Switzerland.

UI MeSH Term Description Entries
D007166 Immunosuppressive Agents Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging. Immunosuppressant,Immunosuppressive Agent,Immunosuppressants,Agent, Immunosuppressive,Agents, Immunosuppressive
D007668 Kidney Body organ that filters blood for the secretion of URINE and that regulates ion concentrations. Kidneys
D008099 Liver A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances. Livers
D008297 Male Males
D009929 Organ Size The measurement of an organ in volume, mass, or heaviness. Organ Volume,Organ Weight,Size, Organ,Weight, Organ
D011919 Rats, Inbred Strains Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding. August Rats,Inbred Rat Strains,Inbred Strain of Rat,Inbred Strain of Rats,Inbred Strains of Rats,Rat, Inbred Strain,August Rat,Inbred Rat Strain,Inbred Strain Rat,Inbred Strain Rats,Inbred Strains Rat,Inbred Strains Rats,Rat Inbred Strain,Rat Inbred Strains,Rat Strain, Inbred,Rat Strains, Inbred,Rat, August,Rat, Inbred Strains,Rats Inbred Strain,Rats Inbred Strains,Rats, August,Rats, Inbred Strain,Strain Rat, Inbred,Strain Rats, Inbred,Strain, Inbred Rat,Strains, Inbred Rat
D001774 Blood Chemical Analysis An examination of chemicals in the blood. Analysis, Blood Chemical,Chemical Analysis, Blood,Analyses, Blood Chemical,Blood Chemical Analyses,Chemical Analyses, Blood
D001835 Body Weight The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms. Body Weights,Weight, Body,Weights, Body
D003524 Cyclosporins A group of closely related cyclic undecapeptides from the fungi Trichoderma polysporum and Cylindocarpon lucidum. They have some antineoplastic and antifungal action and significant immunosuppressive effects. Cyclosporins have been proposed as adjuvants in tissue and organ transplantation to suppress graft rejection. Cyclosporines
D003643 Death Irreversible cessation of all bodily functions, manifested by absence of spontaneous breathing and total loss of cardiovascular and cerebral functions. End Of Life,End-Of-Life,Near-Death Experience,Cardiac Death,Determination of Death,Death, Cardiac

Related Publications

P Donatsch, and J Mason, and B P Richardson, and B Ryffel
Physiologically based pharmacokinetic study on a cyclosporin derivative, SDZ IMM 125.
October 1994, Journal of pharmacokinetics and biopharmaceutics,
P Donatsch, and J Mason, and B P Richardson, and B Ryffel
A new cyclosporin derivative, SDZ-IMM-125, prolongs renal allograft survival in dogs.
June 1995, Transplant immunology,
P Donatsch, and J Mason, and B P Richardson, and B Ryffel
New cyclosporine derivative SDZ IMM 125: in vitro and in vivo pharmacologic effects and toxicologic evaluation.
February 1993, Transplantation proceedings,
P Donatsch, and J Mason, and B P Richardson, and B Ryffel
Human liver cytochrome P4503A biotransformation of the cyclosporin derivative SDZ IMM 125.
March 1995, Drug metabolism and disposition: the biological fate of chemicals,
P Donatsch, and J Mason, and B P Richardson, and B Ryffel
A comparative study of cyclosporine and its derivative SDZ IMM-125 in canine renal allografts.
November 1993, Transplantation,
P Donatsch, and J Mason, and B P Richardson, and B Ryffel
The new cyclosporine derivative, SDZ IMM 125: in vitro and in vivo pharmacologic effects.
August 1992, Transplantation proceedings,
P Donatsch, and J Mason, and B P Richardson, and B Ryffel
Absorption and disposition of SDZ IMM 125, a new cyclosporine derivative, in rats after single and repeated administration.
January 1994, Drug metabolism and disposition: the biological fate of chemicals,
P Donatsch, and J Mason, and B P Richardson, and B Ryffel
Comparison of Sandimmun with a new cyclosporin derivative (IMM 125) in renal transplant patients with stable renal function. IMM 125 Multicentre Study Group.
January 1996, Transplant international : official journal of the European Society for Organ Transplantation,
P Donatsch, and J Mason, and B P Richardson, and B Ryffel
Hepatocellular effects of cyclosporine A and its derivative SDZ IMM 125 in vitro.
March 1998, The Journal of pharmacology and experimental therapeutics,
P Donatsch, and J Mason, and B P Richardson, and B Ryffel
Comparative study of cyclosporin A, cyclosporin G, and the novel cyclosporin derivative IMM 125 in isolated glomeruli and cultured rat mesangial cells: a morphometric analysis.
June 1998, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association,
Copied contents to your clipboard!