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Explant cultures of bovine mammary tissue taken from virgin heifers were used to examine adherence, colonization and cytopathogenesis of Streptococcus uberis, Streptococcus agalactiae, Streptococcus dysgalactiae, Staphylococcus aureus and Escherichia coli in the putative target tissue. None of the five bacteria was able to adhere to healthy ductular epithelium but all showed a marked tropism for exposed connective tissue. S. aureus and E. coli induced a marked cytopathic effect in ductular epithelium after 6 hours in culture but the bacteria were not in close association with the affected tissue. No evidence could be found to support the hypothesis that adherence to epithelium might be the first stage in the pathogenesis of mastitis caused by these organisms.
L H Thomas, and
J A Leigh, and
A P Bland, and
R S Cook
April 1977,
Endocrinology,
L H Thomas, and
J A Leigh, and
A P Bland, and
R S Cook
January 1981,
Scandinavian journal of urology and nephrology,
L H Thomas, and
J A Leigh, and
A P Bland, and
R S Cook
February 2007,
The Journal of dairy research,
L H Thomas, and
J A Leigh, and
A P Bland, and
R S Cook
March 1989,
Breast cancer research and treatment,
L H Thomas, and
J A Leigh, and
A P Bland, and
R S Cook
January 1990,
Annals of the New York Academy of Sciences,
L H Thomas, and
J A Leigh, and
A P Bland, and
R S Cook
January 2008,
Methods in molecular biology (Clifton, N.J.),
L H Thomas, and
J A Leigh, and
A P Bland, and
R S Cook
February 1986,
Archives of dermatology,
L H Thomas, and
J A Leigh, and
A P Bland, and
R S Cook
June 2001,
Veterinary microbiology,
L H Thomas, and
J A Leigh, and
A P Bland, and
R S Cook
May 2000,
Matrix biology : journal of the International Society for Matrix Biology,
L H Thomas, and
J A Leigh, and
A P Bland, and
R S Cook
January 1991,
Steroids,
